2AB1

X-Ray Structure of Gene Product from Homo Sapiens HS.95870

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ab1a1	Alpha and beta proteins (a/b)	MTH938-like	MTH938-like	MTH938-like	Hypothetical protein PTD015 (C11orf67)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2ab1a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ab1b2	Alpha and beta proteins (a/b)	MTH938-like	MTH938-like	MTH938-like	Hypothetical protein PTD015 (C11orf67)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ab1b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MTH938-like	8043988	3000734	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MTH938-like	8043988	3000734	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF498	e2ab1A1	A: a/b three-layered sandwiches	X: Hypothetical protein MT938 (MTH938) (From Topology)	H: Hypothetical protein MT938 (MTH938) (From Topology)	T: Hypothetical protein MT938 (MTH938)	F: DUF498	ECOD (1.6)
B	DUF498	e2ab1B1	A: a/b three-layered sandwiches	X: Hypothetical protein MT938 (MTH938) (From Topology)	H: Hypothetical protein MT938 (MTH938) (From Topology)	T: Hypothetical protein MT938 (MTH938)	F: DUF498	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1230.10	Alpha Beta	3-Layer(aba) Sandwich	Hypothetical Protein Mth938	Chain: A,	CATH (4.3.0)
B	3.40.1230.10	Alpha Beta	3-Layer(aba) Sandwich	Hypothetical Protein Mth938	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF04430	Protein of unknown function (DUF498/DUF598) (DUF498)	Protein of unknown function (DUF498/DUF598)	This is a large family of uncharacterised proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers ...	This is a large family of uncharacterised proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	hypothetical protein	-	developmental process fat cell differentiation regulation of biological process positive regulation of fat cell differentiation regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation cellular process developmental process fat cell differentiation regulation of biological process positive regulation of fat cell differentiation regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation cellular process regulation of fat cell differentiation positive regulation of cellular process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR034096	Mth938 domain-containing protein	Family
A, B	IPR036748	MTH938-like superfamily	Homologous Superfamily
A, B	IPR007523	NDUFAF3/Mth938 domain-containing protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9H7C9	cutaneous lupus erythematosus invasive ductal breast carcinoma malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis ductal breast carcinoma in situ juvenile dermatomyositis myopathy psoriasis interstitial cystitis lung adenocarcinoma ovarian cancer subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.