Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilySialidases (neuraminidases) 8024629 4002683 SCOP2 (2022-06-29)
ASCOP2 FamilyTrypanosoma sialidase, C-terminal domain 8024630 4002559 SCOP2 (2022-06-29)
ASCOP2 SuperfamilySialidases 8037008 3001607 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyConcanavalin A-like lectins/glucanases 8037009 3000120 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALaminin_G_3e2ah2A1 A: beta sandwichesX: jelly-rollH: Concanavalin A-likeT: Concanavalin A-like lectins/glucanasesF: Laminin_G_3ECOD (1.6)
ABNR_2e2ah2A2 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 6-bladedF: BNR_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.120.10.10 Mainly Beta 6 Propeller Neuraminidase CATH (4.3.0)
A2.60.120.200 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF13859BNR repeat-like domain (BNR_3)BNR repeat-like domain- Repeat
PF22925Trans-sialidase, C-terminal domain (TS_C)Trans-sialidase, C-terminal domainThis domain is found C-terminal in a number of Trans-sialidases (TS) from Trypanosoma cruzi and other related species. The Trypanosoma TS is involved in host cell invasion and parasite survival in the bloodstream. The parasite uses TS activity to sia ...This domain is found C-terminal in a number of Trans-sialidases (TS) from Trypanosoma cruzi and other related species. The Trypanosoma TS is involved in host cell invasion and parasite survival in the bloodstream. The parasite uses TS activity to sialylate its own surface molecules, allowing it to evade lysis by serum factors. This domain follows the catalytic domain and adopts a beta-sandwich fold typical for Concanavalin-like lectin/glucanase superfamily. It is likely involved in binding glycan structures present on the surface of the Trypanosomes or host cells and in modulating the activity and biological function of TS [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
trans-sialidase