2AL6

FERM domain of Focal Adhesion Kinase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2al6a1	All alpha proteins	Acyl-CoA binding protein-like	Second domain of FERM	Second domain of FERM	Focal adhesion kinase 1	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d2al6a2	All beta proteins	PH domain-like barrel	PH domain-like	Third domain of FERM	Focal adhesion kinase 1	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d2al6a3	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	First domain of FERM	Focal adhesion kinase 1	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d2al6b1	All alpha proteins	Acyl-CoA binding protein-like	Second domain of FERM	Second domain of FERM	Focal adhesion kinase 1	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d2al6b2	All beta proteins	PH domain-like barrel	PH domain-like	Third domain of FERM	Focal adhesion kinase 1	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d2al6b3	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	First domain of FERM	Focal adhesion kinase 1	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ubiquitin-like	8037190	3000157	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	FERM central domain-like	8037187	3001227	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PH domain-like	8037188	3000134	SCOP2B (2022-06-29)
B	SCOP2 Family	FERM domain-like	8024808	4000747	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	FERM central domain-like	8037187	3001227	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	PH domain-like	8037188	3000134	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Ubiquitin-like	8037190	3000157	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FERM_C_FAK1	e2al6A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: FERM_C_FAK1	ECOD (1.6)
A	FERM_M	e2al6A2	A: alpha bundles	X: Acyl-CoA binding protein-like (From Topology)	H: Acyl-CoA binding protein-like (From Topology)	T: Acyl-CoA binding protein-like	F: FERM_M	ECOD (1.6)
A	KOG4257	e2al6A3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: KOG4257	ECOD (1.6)
B	FERM_C_FAK1	e2al6B5	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: FERM_C_FAK1	ECOD (1.6)
B	FERM_M	e2al6B4	A: alpha bundles	X: Acyl-CoA binding protein-like (From Topology)	H: Acyl-CoA binding protein-like (From Topology)	T: Acyl-CoA binding protein-like	F: FERM_M	ECOD (1.6)
B	KOG4257	e2al6B3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: KOG4257	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
A	1.20.80.10	Mainly Alpha	Up-down Bundle	Acyl-CoA Binding Protein		CATH (4.3.0)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
B	1.20.80.10	Mainly Alpha	Up-down Bundle	Acyl-CoA Binding Protein		CATH (4.3.0)
B	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21477	FAK1/PYK2, FERM domain C-lobe (FERM_C_FAK1)	FAK1/PYK2, FERM domain C-lobe	FAK1 (focal adhesion kinase 1) is a non-receptor tyrosine kinase that localizes to focal adhesions in adherent cells and it is involved in diverse cellular roles. The N-terminal region of FAK1 contains a FERM domain which is subdivided FERM_N or A-lo ...	FAK1 (focal adhesion kinase 1) is a non-receptor tyrosine kinase that localizes to focal adhesions in adherent cells and it is involved in diverse cellular roles. The N-terminal region of FAK1 contains a FERM domain which is subdivided FERM_N or A-lobe, FERM_M or B-lobe and FERM_C or C-lobe. This entry represents the C-lobe, which is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites [1-5]. This domain is also present in protein-tyrosine kinase 2-beta (also known as PYK2), a cytoplasmic, non-receptor tyrosine kinase which is a close paralogue to FAK in vertebrates. FRMPD1/3/4 also contain this domain; FRMPD1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. FRMPD4 has been shown to regulate dendritic spine morphogenesis and the function of FRMPD3 is not clear.	Domain
A, B	PF00373	FERM central domain (FERM_M)	FERM central domain	This domain is the central structural domain of the FERM domain.	Domain
A, B	PF18038	FERM N-terminal domain (FERM_N_2)	FERM N-terminal domain	This entry represents the FERM N-terminal domain found in focal adhesion kinases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Focal adhesion kinase 1	cysteine-type peptidase activity peptidase activity calcium-dependent cysteine-type endopeptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity protein tyrosine kinase activity kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cysteine-type peptidase activity peptidase activity calcium-dependent cysteine-type endopeptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity protein tyrosine kinase activity kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding non-membrane spanning protein tyrosine kinase activity identical protein binding protein binding enzyme binding protease binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding molecular function activator activity molecular function regulator activity	regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process positive regulation of locomotion regulation of cell motility regulation of substrate-dependent cell migration, cell attachment to substrate positive regulation of biological process positive regulation of cell migration positive regulation of cell-substrate adhesion positive regulation of cell motility regulation of cell migration regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process positive regulation of locomotion regulation of cell motility regulation of substrate-dependent cell migration, cell attachment to substrate positive regulation of biological process positive regulation of cell migration positive regulation of cell-substrate adhesion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion cell-substrate adhesion regulation of locomotion substrate-dependent cell migration substrate-dependent cell migration, cell attachment to substrate positive regulation of substrate-dependent cell migration, cell attachment to substrate negative regulation of programmed cell death regulation of apoptotic process regulation of anoikis negative regulation of biological process regulation of programmed cell death cell death negative regulation of anoikis negative regulation of apoptotic process anoikis negative regulation of cellular process apoptotic process programmed cell death positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of molecular function positive regulation of kinase activity regulation of protein tyrosine kinase activity regulation of kinase activity macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of molecular function positive regulation of protein modification process positive regulation of peptidyl-tyrosine phosphorylation protein metabolic process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of protein tyrosine kinase activity regulation of peptidyl-tyrosine phosphorylation positive regulation of catalytic activity regulation of macromolecule metabolic process regulation of protein kinase activity regulation of phosphorylation peptidyl-tyrosine phosphorylation regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component organization cellular component biogenesis cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly protein autophosphorylation cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication ERBB signaling pathway epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling protein-containing complex organization regulation of signal transduction signal complex assembly regulation of response to stimulus protein-containing complex assembly regulation of cell communication organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization developmental process multicellular organismal process wound healing blood vessel morphogenesis tube development angiogenesis involved in wound healing angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis response to stress anatomical structure development anatomical structure formation involved in morphogenesis response to wounding blood vessel development system development regulation of protein binding positive regulation of protein binding regulation of binding positive regulation of binding negative regulation of phosphate metabolic process negative regulation of cellular metabolic process negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process regulation of protein autophosphorylation negative regulation of protein phosphorylation negative regulation of phosphorus metabolic process negative regulation of phosphorylation negative regulation of protein autophosphorylation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation response to pH response to abiotic stimulus negative regulation of cell adhesion negative regulation of cell-substrate adhesion neuron migration cellular developmental process nervous system development generation of neurons neurogenesis cell differentiation radial glia-guided pyramidal neuron migration epithelium development morphogenesis of an epithelium epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet tissue morphogenesis epiboly wound healing, spreading of cells response to mechanical stimulus response to external stimulus response to muscle stretch	cell periphery sarcolemma plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection cell periphery sarcolemma plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite dendritic tree perinuclear region of cytoplasm membrane-bounded organelle cilium intracellular organelle ciliary basal body microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle anchoring junction focal adhesion cell-substrate junction cell cortex centrosome nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000299	FERM domain	Domain
A, B	IPR041784	FAK1/PYK2, FERM domain C-lobe	Domain
A, B	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B	IPR019748	FERM central domain	Domain
A, B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR041390	Focal adhesion kinase, N-terminal	Domain
A, B	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A, B	IPR036137	Focal adhesion kinase, targeting (FAT) domain superfamily	Homologous Superfamily
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A, B	IPR049385	FAK1-like, FERM domain C-lobe	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR019749	Band 4.1 domain	Domain
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR005189	Focal adhesion kinase, targeting (FAT) domain	Domain
A, B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.