2BR9

14-3-3 Protein Epsilon (Human) Complexed to Peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2br9a_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	14-3-3 protein	8082820	4001338	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	14-3-3 protein	8082821	3001329	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	14-3-3	e2br9A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00244	14-3-3 protein (14-3-3)	14-3-3 protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	14-3-3 PROTEIN EPSILON	histone deacetylase binding protein binding binding enzyme binding phosphoprotein binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity protein phosphatase binding histone deacetylase binding protein binding binding enzyme binding phosphoprotein binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity protein phosphatase binding phosphatase binding cell adhesion molecule binding cadherin binding molecular function inhibitor activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity channel inhibitor activity potassium channel regulator activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding protein domain specific binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity phosphoserine residue binding protein phosphorylated amino acid binding protein heterodimerization activity protein dimerization activity scaffold protein binding molecular sequestering activity protein sequestering activity RNA binding organic cyclic compound binding nucleic acid binding transmembrane transporter binding	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus intracellular signal transduction cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus intracellular signal transduction cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response protein localization localization cellular localization cellular macromolecule localization macromolecule localization heart process multicellular organismal process regulation of heart rate by chemical signal system process regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction regulation of heart rate by hormone blood circulation regulation of heart rate cellular response to heat cellular response to stress response to heat response to abiotic stimulus response to temperature stimulus inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis intracellular signaling cassette MAPK cascade developmental process head development forebrain development animal organ development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development anatomical structure development telencephalon development system development establishment of protein localization protein targeting establishment of localization cardiac conduction regulation of heart rate by cardiac conduction toll-like receptor signaling pathway negative regulation of biological process regulation of signal transduction regulation of pattern recognition receptor signaling pathway regulation of toll-like receptor signaling pathway negative regulation of signaling negative regulation of cell communication negative regulation of cellular process regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction negative regulation of toll-like receptor signaling pathway negative regulation of immune system process regulation of cell communication hippocampus development limbic system development regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle membrane repolarization regulation of membrane repolarization regulation of membrane potential maintenance of protein location cytoplasmic sequestering of protein maintenance of location regulation of localization regulation of potassium ion transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport hippo signaling positive regulation of cell communication positive regulation of signal transduction regulation of intracellular signal transduction positive regulation of cellular process positive regulation of intracellular signal transduction positive regulation of hippo signaling regulation of hippo signaling positive regulation of signaling regulation of calcium ion transport negative regulation of monoatomic ion transport negative regulation of transport export across plasma membrane negative regulation of calcium ion export across plasma membrane calcium ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cation transmembrane transport regulation of calcium ion export across plasma membrane calcium ion export across plasma membrane export from cell negative regulation of calcium ion transport negative regulation of calcium ion transmembrane transport calcium ion transmembrane transport nitrogen compound transport regulation of protein localization nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization positive regulation of protein transport establishment of localization in cell positive regulation of intracellular transport nuclear export regulation of protein export from nucleus regulation of intracellular transport regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport regulation of protein transport protein export from nucleus positive regulation of protein export from nucleus positive regulation of transport protein transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport substantia nigra development midbrain development neural nucleus development protein localization to organelle protein localization to endoplasmic reticulum cardiac muscle cell membrane repolarization membrane repolarization during cardiac muscle cell action potential action potential cardiac muscle cell action potential membrane repolarization during action potential neuron migration cellular developmental process generation of neurons neurogenesis cell differentiation cell migration cell motility protein localization to nucleus	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope cytoplasm organelle membrane cytosol anchoring junction cell junction focal adhesion cell-substrate junction pigment granule intracellular vesicle melanosome cytoplasmic vesicle nucleus endoplasmic reticulum endomembrane system
B [auth P]	CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023409	14-3-3 protein, conserved site	Conserved Site
A	IPR023410	14-3-3 domain	Domain
A	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A	IPR000308	14-3-3 protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P62258	Miller-Dieker lissencephaly syndrome endometrioid stromal sarcoma chromosome 17p13.3 duplication syndrome Neoplasm Metastasis schizophrenia Parkinson disease psoriasis atrial fibrillation Down syndrome Gerstmann-Straussler-Scheinker syndrome large cell medulloblastoma osteosarcoma Pick disease rheumatoid arthritis atypical teratoid rhabdoid tumor Miller-Dieker lissencephaly syndrome endometrioid stromal sarcoma chromosome 17p13.3 duplication syndrome Neoplasm Metastasis schizophrenia Parkinson disease psoriasis atrial fibrillation Down syndrome Gerstmann-Straussler-Scheinker syndrome large cell medulloblastoma osteosarcoma Pick disease rheumatoid arthritis atypical teratoid rhabdoid tumor clear cell sarcoma of kidney hereditary spastic paraplegia malignant ependymoma ovarian cancer plasma cell myeloma bipolar disorder dermatomyositis interstitial cystitis medulloblastoma oligodendroglioma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth P]	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.