2BUU

Crystal Structure Of Protocatechuate 3,4-Dioxygenase from Acinetobacter Sp. ADP1 Mutant R457S in complex with 4-Nitrocatechol

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2buua_	All beta proteins	Prealbumin-like	Aromatic compound dioxygenase	Aromatic compound dioxygenase	automated matches	(Acinetobacter baylyi ADP1 ) [TaxId: 62977 ],	SCOPe (2.08)
B	d2buub_	All beta proteins	Prealbumin-like	Aromatic compound dioxygenase	Aromatic compound dioxygenase	automated matches	(Acinetobacter baylyi ADP1 ) [TaxId: 62977 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Aromatic compound dioxygenase	8038660	3000868	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Aromatic compound dioxygenase	8038661	3000868	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Dioxygenase_C	e2buuA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: Dioxygenase_C	ECOD (1.6)
B	Dioxygenase_C	e2buuB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: Dioxygenase_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.130.10	Mainly Beta	Sandwich	Protocatechuate 3,4-Dioxygenase, subunit A	Aromatic compound dioxygenase	CATH (4.3.0)
B	2.60.130.10	Mainly Beta	Sandwich	Protocatechuate 3,4-Dioxygenase, subunit A	Aromatic compound dioxygenase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00775	Dioxygenase (Dioxygenase_C)	Dioxygenase	-	Domain
B	PF12391	Protocatechuate 3,4-dioxygenase beta subunit N terminal (PCDO_beta_N)	Protocatechuate 3,4-dioxygenase beta subunit N terminal	-	Family
B	PF00775	Dioxygenase (Dioxygenase_C)	Dioxygenase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTOCATECHUATE 3,4-DIOXYGENASE ALPHA CHAIN	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity protocatechuate 3,4-dioxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity cation binding ferric iron binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding	catabolic process beta-ketoadipate pathway metabolic process cellular process	-
B	PROTOCATECHUATE 3,4-DIOXYGENASE BETA CHAIN	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity protocatechuate 3,4-dioxygenase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity cation binding ferric iron binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding	catabolic process 3,4-dihydroxybenzoate metabolic process benzene-containing compound metabolic process oxoacid metabolic process catechol-containing compound catabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process catechol-containing compound metabolic process organic acid metabolic process organic acid catabolic process phenol-containing compound catabolic process cellular catabolic process monocarboxylic acid catabolic process organic hydroxy compound catabolic process carboxylic acid catabolic process catabolic process 3,4-dihydroxybenzoate metabolic process benzene-containing compound metabolic process oxoacid metabolic process catechol-containing compound catabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process catechol-containing compound metabolic process organic acid metabolic process organic acid catabolic process phenol-containing compound catabolic process cellular catabolic process monocarboxylic acid catabolic process organic hydroxy compound catabolic process carboxylic acid catabolic process phenol-containing compound metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process 3,4-dihydroxybenzoate catabolic process small molecule catabolic process beta-ketoadipate pathway	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012786	Protocatechuate 3,4-dioxygenase, alpha subunit	Family
A	IPR050770	Intradiol Ring-Cleavage Dioxygenase	Family
A	IPR000627	Intradiol ring-cleavage dioxygenase, C-terminal	Domain
A	IPR015889	Intradiol ring-cleavage dioxygenase, core	Homologous Superfamily
B	IPR050770	Intradiol Ring-Cleavage Dioxygenase	Family
B	IPR012785	Protocatechuate 3,4-dioxygenase, beta subunit	Family
B	IPR000627	Intradiol ring-cleavage dioxygenase, C-terminal	Domain
B	IPR024756	Protocatechuate 3,4-dioxygenase beta subunit, N-terminal	Domain
B	IPR015889	Intradiol ring-cleavage dioxygenase, core	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.