2C2L

Crystal structure of the CHIP U-box E3 ubiquitin ligase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2c2la1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d2c2la2	Small proteins	RING/U-box	RING/U-box	U-box	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2c2lb1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2c2lb2	Small proteins	RING/U-box	RING/U-box	U-box	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d2c2lc1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d2c2lc2	Small proteins	RING/U-box	RING/U-box	U-box	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d2c2ld1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d2c2ld2	Small proteins	RING/U-box	RING/U-box	U-box	STIP1 homology and U box-containing protein 1, STUB1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Tetratricopeptide repeat (TPR)	8026751	4001344	SCOP2 (2022-06-29)
A	SCOP2 Family	U-box	8026753	4003890	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	TPR-like	8039130	3001345	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RING/U-box like	8039132	3000160	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	TPR-like	8039130	3001345	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RING/U-box like	8039132	3000160	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TPR-like	8039130	3001345	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RING/U-box like	8039132	3000160	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RING/U-box like	8039132	3000160	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	TPR-like	8039130	3001345	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG4642,TPR_11_4	e2c2lA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG4642,TPR_11_4	ECOD (1.6)
A	U-box	e2c2lA2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: U-box	ECOD (1.6)
B	KOG4642,TPR_11_4	e2c2lB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG4642,TPR_11_4	ECOD (1.6)
B	U-box	e2c2lB2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: U-box	ECOD (1.6)
C	KOG4642,TPR_11_4	e2c2lC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG4642,TPR_11_4	ECOD (1.6)
C	U-box	e2c2lC2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: U-box	ECOD (1.6)
D	KOG4642,TPR_11_4	e2c2lD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG4642,TPR_11_4	ECOD (1.6)
D	U-box	e2c2lD2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: U-box	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
A	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
B	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
B	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
C	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
C	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)
D	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
D	3.30.40.10	Alpha Beta	2-Layer Sandwich	Herpes Virus-1	Zinc/RING finger domain, C3HC4 (zinc finger)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
A, B, C, D	PF04564	U-box domain (U-box)	U-box domain	The U-box is a domain of ~70 amino acids that is present in proteins from yeast to human. It consists of the beta-beta-alpha-beta-alpha- fold typical of U-box and RING domains. The central alpha helix is flanked by two prominent surface-exposed loop ...	The U-box is a domain of ~70 amino acids that is present in proteins from yeast to human. It consists of the beta-beta-alpha-beta-alpha- fold typical of U-box and RING domains. The central alpha helix is flanked by two prominent surface-exposed loop regions. This domain is one class of E3 ligases, involved in the ubiquitination process [1-3]. This domain is related to the Ring finger Pfam:PF00097 but lacks the zinc binding residues [4].	Domain
A, B, C, D	PF18391	CHIP N-terminal tetratricopeptide repeat domain (CHIP_TPR_N)	CHIP N-terminal tetratricopeptide repeat domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	CARBOXY TERMINUS OF HSP70-INTERACTING PROTEIN	SMAD binding protein binding binding R-SMAD binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SMAD binding protein binding binding R-SMAD binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity misfolded protein binding heat shock protein binding protein-folding chaperone binding protein-macromolecule adaptor activity molecular adaptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding Hsp90 protein binding Hsp70 protein binding kinase binding identical protein binding protein homodimerization activity protein dimerization activity TPR domain binding protein domain specific binding signaling receptor binding G protein-coupled receptor binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis cellular process metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress protein folding biosynthetic process gene expression macromolecule biosynthetic process protein maturation response to ischemia response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus cellular response to heat response to heat response to temperature stimulus protein autoubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of proteasomal protein catabolic process regulation of cellular process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction regulation of hormone metabolic process regulation of hormone levels steroid metabolic process regulation of steroid metabolic process regulation of lipid metabolic process hormone metabolic process glucocorticoid metabolic process regulation of glucocorticoid metabolic process lipid metabolic process protein polyubiquitination negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus negative regulation of signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA damage response DNA repair regulation of cellular component organization positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of chaperone-mediated protein complex assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly chaperone-mediated protein complex assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of chaperone-mediated protein complex assembly cellular response to misfolded protein response to misfolded protein cellular response to topologically incorrect protein response to topologically incorrect protein autophagy chaperone-mediated autophagy process utilizing autophagic mechanism protein monoubiquitination endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein regulation of protein modification process regulation of catalytic activity regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification positive regulation of molecular function positive regulation of protein modification process regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification positive regulation of catalytic activity positive regulation of ubiquitin-protein transferase activity positive regulation of programmed cell death positive regulation of smooth muscle cell apoptotic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process positive regulation of apoptotic process positive regulation of muscle cell apoptotic process apoptotic process programmed cell death protein K63-linked ubiquitination macroautophagy regulation of autophagy positive regulation of autophagy of mitochondrion mitophagy regulation of autophagy of mitochondrion positive regulation of macroautophagy positive regulation of autophagy positive regulation of mitophagy regulation of mitophagy regulation of macroautophagy autophagy of mitochondrion protein quality control for misfolded or incompletely synthesized proteins negative regulation of programmed cell death negative regulation of smooth muscle cell apoptotic process negative regulation of apoptotic process negative regulation of muscle cell apoptotic process regulation of cellular response to stress regulation of ERAD pathway positive regulation of ERAD pathway regulation of response to endoplasmic reticulum stress positive regulation of response to stimulus positive regulation of response to endoplasmic reticulum stress regulation of response to stress	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cytosol protein-containing complex protein folding chaperone complex intracellular protein-containing complex membrane-bounded organelle inclusion body nucleus intracellular membrane-bounded organelle nuclear inclusion body ubiquitin ligase complex catalytic complex transferase complex mitochondrion membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen ubiquitin conjugating enzyme complex endoplasmic reticulum endomembrane system
E, F, G, H	HSP90	histone deacetylase binding protein binding binding enzyme binding protein phosphatase binding phosphatase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding histone deacetylase binding protein binding binding enzyme binding protein phosphatase binding phosphatase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding adenyl deoxyribonucleotide binding deoxyribonucleotide binding purine deoxyribonucleotide binding dATP binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding protein tyrosine kinase binding kinase binding protein kinase binding pyrimidine ribonucleotide binding CTP binding pyrimidine nucleotide binding scaffold protein binding guanyl nucleotide binding GTP binding guanyl ribonucleotide binding GTPase binding sulfonylurea receptor binding signaling receptor binding identical protein binding protein homodimerization activity protein dimerization activity TPR domain binding protein domain specific binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity protein-containing complex binding MHC protein complex binding MHC class II protein complex binding RNA binding nucleic acid binding mRNA binding cytoskeletal protein binding tau protein binding enzyme regulator activity molecular function regulator activity nitric-oxide synthase regulator activity Rho GDP-dissociation inhibitor binding GDP-dissociation inhibitor binding ATP-dependent protein folding chaperone protein folding chaperone UTP binding transmembrane transporter binding unfolded protein binding DNA polymerase binding disordered domain specific binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process response to stimulus response to chemical response to xenobiotic stimulus regulation of protein stability regulation of biological quality protein stabilization response to stress response to abiotic stimulus response to cold response to temperature stimulus ribonucleoprotein complex biogenesis telomerase holoenzyme complex assembly protein-containing complex organization protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis response to topologically incorrect protein response to unfolded protein response to antibiotic cellular response to stimulus cellular response to heat cellular response to stress response to heat positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of tau-protein kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity regulation of tau-protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of phosphorylation regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus regulation of defense response to virus defense response to virus regulation of response to stimulus defense response to other organism regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to external biotic stimulus response to virus response to osmotic stress response to salt stress telomere maintenance via telomerase telomere organization chromosome organization DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening telomere maintenance nucleic acid biosynthetic process organelle organization DNA biosynthetic process chaperone-mediated protein complex assembly multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction catabolic process macromolecule catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process positive regulation of macromolecule biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process regulation of interferon-beta production interferon-beta production positive regulation of type I interferon production type I interferon production gene expression regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of interferon-beta production positive regulation of cytokine production regulation of type I interferon production protein unfolding protein localization regulation of localization cellular localization regulation of protein localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of post-translational protein modification regulation of protein ubiquitination protein ubiquitination regulation of protein modification by small protein conjugation or removal post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of cell size regulation of cellular component size regulation of cell size regulation of anatomical structure size transport establishment of localization mitochondrial transport regulation of cellular component organization positive regulation of cellular component organization cell projection organization plasma membrane bounded cell projection assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization lamellipodium assembly plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly positive regulation of lamellipodium assembly regulation of cellular component biogenesis positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly protein polymerization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly regulation of protein polymerization positive regulation of protein polymerization protein refolding protein maturation protein folding regulation of postsynaptic membrane neurotransmitter receptor levels regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death establishment of protein localization nitrogen compound transport nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport import into nucleus regulation of protein import into nucleus establishment of localization in cell protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport positive regulation of transport establishment of protein localization to organelle protein transport protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport autophagy chaperone-mediated autophagy process utilizing autophagic mechanism muscle cell apoptotic process striated muscle cell apoptotic process cardiac muscle cell apoptotic process heart process regulation of heart contraction regulation of system process positive regulation of blood circulation positive regulation of cardiac muscle contraction cardiac muscle contraction circulatory system process positive regulation of striated muscle contraction blood circulation regulation of cardiac muscle contraction regulation of muscle system process positive regulation of heart contraction regulation of blood circulation regulation of striated muscle contraction regulation of muscle contraction positive regulation of muscle contraction heart contraction positive regulation of response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response innate immune response regulation of immune system process positive regulation of immune system process positive regulation of innate immune response immune response regulation of innate immune response immune system process positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response response to hormone response to endogenous stimulus response to estrogen developmental process neuron migration cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation anatomical structure development cell migration cell motility system development establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization outer mitochondrial membrane organization mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane localization within membrane protein localization to membrane protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion response to oxygen-containing compound response to nitrogen compound response to organic cyclic compound response to cocaine response to alkaloid cellular response to virus	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane sperm plasma membrane growth cone axon cell projection distal axon neuron projection axonal growth cone cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane sperm plasma membrane growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth apical part of cell plasma membrane region apical plasma membrane cell surface protein-containing complex extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle vesicle brush border membrane cluster of actin-based cell projections brush border cell projection membrane endocytic vesicle lumen endocytic vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular space extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix dendrite terminus somatodendritic compartment dendritic growth cone dendrite dendritic tree basal part of cell basal plasma membrane basolateral plasma membrane perinuclear region of cytoplasm cell body neuronal cell body mitochondrion myelin sheath pigment granule melanosome lytic vacuole vacuolar lumen vacuole lysosomal lumen lysosome ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen sperm midpiece cilium 9+2 motile cilium motile cilium sperm mitochondrial sheath sperm flagellum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR019734	Tetratricopeptide repeat	Repeat
A, B, C, D	IPR003613	U-box domain	Domain
A, B, C, D	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B, C, D	IPR045202	CHIP , U-box domain	Domain
A, B, C, D	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B, C, D	IPR041312	CHIP, N-terminal tetratricopeptide repeat domain	Domain
E, F, G, H	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
E, F, G, H	IPR001404	Heat shock protein Hsp90 family	Family
E, F, G, H	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
E, F, G, H	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
E, F, G, H	IPR019805	Heat shock protein Hsp90, conserved site	Conserved Site
E, F, G, H	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
E, F, G, H	IPR037196	HSP90, C-terminal domain	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E, F, G, H	Pharos: P07900	anaplastic large cell lymphoma contact dermatitis HIV infectious disease breast cancer Neoplasm Metastasis breast carcinoma osteosarcoma plasma cell myeloma Sjogren syndrome breast disease exocrine pancreatic carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm ovarian cancer anaplastic large cell lymphoma contact dermatitis HIV infectious disease breast cancer Neoplasm Metastasis breast carcinoma osteosarcoma plasma cell myeloma Sjogren syndrome breast disease exocrine pancreatic carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm ovarian cancer psoriasis cancer hematologic disease juvenile dermatomyositis lung cancer major depressive disorder pancreatic ductal adenocarcinoma sinusitis cystic fibrosis large cell medulloblastoma lung disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.