2C5L

Structure of PLC epsilon Ras association domain with hRas

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2c5la_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2c5lb_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases G proteins automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2c5ld_ Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like Ras-binding domain, RBD automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2c5lc1 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) Ubiquitin-like Ras-binding domain, RBD Phospholipase C-epsilon-1 HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRas-like P-loop GTPases 8019405 3002022 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyRas-like P-loop GTPases 8019405 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARase2c5lA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
BRase2c5lB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
DRA_1e2c5lD1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: RA_1ECOD (1.6)
CRA_1e2c5lC1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: RA_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
B3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
D3.10.20.90 Alpha Beta Roll Ubiquitin-like (UB roll) Phosphatidylinositol 3-kinase Catalytic SubunitCATH (4.3.0)
C3.10.20.90 Alpha Beta Roll Ubiquitin-like (UB roll) Phosphatidylinositol 3-kinase Catalytic SubunitCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain
C, D
PF00788Ras association (RalGDS/AF-6) domain (RA)Ras association (RalGDS/AF-6) domainRasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure [3] similar to that determined [1], and that of th ...RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure [3] similar to that determined [1], and that of the RasGTP-binding domain of Raf kinase.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
GTPASE HRAS
C, D
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C PLC-EPSILON

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B
IPR020849Small GTPase, Ras-typeFamily
A, B
IPR005225Small GTP-binding domainDomain
A, B
IPR001806Small GTPaseFamily
C, D
IPR0469741-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, EF-hand domainDomain
C, D
IPR001711Phospholipase C, phosphatidylinositol-specific, Y domainDomain
C, D
IPR000008C2 domainDomain
C, D
IPR000909Phosphatidylinositol-specific phospholipase C, X domainDomain
C, D
IPR001895Ras guanine-nucleotide exchange factors catalytic domainDomain
C, D
IPR011992EF-hand domain pairHomologous Superfamily
C, D
IPR000159Ras-associating domainDomain
C, D
IPR015359Phosphoinositide-specific phospholipase C, EF-hand-like domainDomain
C, D
IPR001192Phosphoinositide phospholipase C familyFamily
C, D
IPR0469731-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, catalytic domainDomain
C, D
IPR017946PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyHomologous Superfamily
C, D
IPR0283981-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, RA domain 2Domain
C, D
IPR036964Ras guanine-nucleotide exchange factor, catalytic domain superfamilyHomologous Superfamily
C, D
IPR035892C2 domain superfamilyHomologous Superfamily
C, D
IPR023578Ras guanine nucleotide exchange factor domain superfamilyHomologous Superfamily
C, D
IPR029071Ubiquitin-like domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B
Pharos:  P01112
C, D
Pharos:  Q9P212