2CB6

Crystal structure of the catalytic domain of the mosquitocidal toxin from Bacillus sphaericus, mutant E195Q

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	Enterotoxin_a	e2cb6E2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
F	Enterotoxin_a	e2cb6F2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
G	Enterotoxin_a	e2cb6G2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
H	Enterotoxin_a	e2cb6H2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
I	Enterotoxin_a	e2cb6I2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
J	Enterotoxin_a	e2cb6J2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
K	Enterotoxin_a	e2cb6K2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
N	Enterotoxin_a	e2cb6N2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
P	Enterotoxin_a	e2cb6P2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
A	Enterotoxin_a	e2cb6A2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
B	Enterotoxin_a	e2cb6B2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
C	Enterotoxin_a	e2cb6C2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
D	Enterotoxin_a	e2cb6D2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
L	Enterotoxin_a	e2cb6L2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
M	Enterotoxin_a	e2cb6M2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)
O	Enterotoxin_a	e2cb6O2	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Enterotoxin_a	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
F	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
G	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
H	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
I	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
J	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
K	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
N	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
P	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
A	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
B	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
C	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
D	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
L	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
M	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
O	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF22596	Scabin-like (Scabin-like)	Scabin-like	This entry represents a group of mono-ADP-ribosyltransferase toxins, including scabin (Swiss:C9Z6T8), a novel DNA-targeting enzyme from the plant pathogen Streptomyces scabiei [1,2].	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR035992	Ricin B-like lectins	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR000772	Ricin B, lectin domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.