2CWF

Crystal Structure of delta1-piperideine-2-carboxylate reductase from Pseudomonas syringae complexed with NADPH

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cwfa_	Alpha and beta proteins (a/b)	L-sulfolactate dehydrogenase-like	L-sulfolactate dehydrogenase-like	automated matches	automated matches	(Pseudomonas syringae pv. tomato ) [TaxId: 323 ],	SCOPe (2.08)
B	d2cwfb_	Alpha and beta proteins (a/b)	L-sulfolactate dehydrogenase-like	L-sulfolactate dehydrogenase-like	automated matches	automated matches	(Pseudomonas syringae pv. tomato ) [TaxId: 323 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	L-sulfolactate dehydrogenase-like	8083212	3000527	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	L-sulfolactate dehydrogenase-like	8083212	3000527	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ldh_2	e2cwfA1	A: a+b three layers	X: L-sulfolactate dehydrogenase-like (From Topology)	H: L-sulfolactate dehydrogenase-like (From Topology)	T: L-sulfolactate dehydrogenase-like	F: Ldh_2	ECOD (1.6)
B	Ldh_2	e2cwfB1	A: a+b three layers	X: L-sulfolactate dehydrogenase-like (From Topology)	H: L-sulfolactate dehydrogenase-like (From Topology)	T: L-sulfolactate dehydrogenase-like	F: Ldh_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1530.10	Mainly Alpha	Orthogonal Bundle	Hypothetical Oxidoreductase Yiak	Chain: A, domain 1	CATH (4.3.0)
A	3.30.1370.60	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)
A	3.30.60.50	Alpha Beta	2-Layer Sandwich	Wheat Germ Agglutinin (Isolectin 2)	domain 1	CATH (4.3.0)
B	1.10.1530.10	Mainly Alpha	Orthogonal Bundle	Hypothetical Oxidoreductase Yiak	Chain: A, domain 1	CATH (4.3.0)
B	3.30.1370.60	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)
B	3.30.60.50	Alpha Beta	2-Layer Sandwich	Wheat Germ Agglutinin (Isolectin 2)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02615	Malate/L-lactate dehydrogenase (Ldh_2)	Malate/L-lactate dehydrogenase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	delta1-piperideine-2-carboxylate reductase	NADP+ binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity pyrroline-2-carboxylate reductase activity NADP+ binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity pyrroline-2-carboxylate reductase activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity delta1-piperideine-2-carboxylate reductase activity oxidoreductase activity, acting on the CH-NH2 group of donors N-methylalanine dehydrogenase activity oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process proline metabolic process metabolic process cellular process small molecule metabolic process amine metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process proline metabolic process metabolic process cellular process small molecule metabolic process amine metabolic process methylamine metabolic process primary amino compound metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR043143	Malate/L-sulfolactate/L-lactate dehydrogenase-like, NADPH binding domain	Homologous Superfamily
A, B	IPR043144	Malate/L-sulfolactate/L-lactate dehydrogenase-like, alpha-helical domain	Homologous Superfamily
A, B	IPR003767	Malate/L-lactate dehydrogenase-like	Family
A, B	IPR036111	Malate/L-sulfolactate/L-lactate dehydrogenase-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.