2EEF

Solution structure of the CBM_21 domain from human protein phosphatase 1, regulatory (inhibitor) subunit 3B

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CBM21-like	8051403	4007352	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Starch-binding domain-like	8092811	3000816	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CBM_21	e2eefA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: CBM_21	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.2440	Mainly Beta	Sandwich	Immunoglobulin-like	Carbohydrate binding type-21 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03370	Carbohydrate/starch-binding module (family 21) (CBM_21)	Carbohydrate/starch-binding module (family 21)	This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein Swiss:O08541 has been shown to interact with glycogen synthase, phosphorylase kinase, ph ...	This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein Swiss:O08541 has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localises it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein phosphatase 1, regulatory (Inhibitor) subunit 3B	protein phosphatase binding phosphatase binding protein phosphatase 1 binding protein binding binding enzyme binding polysaccharide binding carbohydrate binding glycogen binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity protein phosphatase binding phosphatase binding protein phosphatase 1 binding protein binding binding enzyme binding polysaccharide binding carbohydrate binding glycogen binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds [phosphorylase] phosphatase activity phosphatase activity hydrolase activity catalytic activity	regulation of glycogen biosynthetic process regulation of cellular process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of glycogen biosynthetic process regulation of cellular process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of biological process polysaccharide biosynthetic process carbohydrate biosynthetic process cellular metabolic process glycogen metabolic process biological regulation primary metabolic process regulation of cellular metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process regulation of cellular biosynthetic process biosynthetic process regulation of polysaccharide biosynthetic process metabolic process cellular process energy reserve metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of carbohydrate biosynthetic process regulation of glycogen metabolic process regulation of metabolic process negative regulation of cellular catabolic process catabolic process negative regulation of biological process carbohydrate catabolic process negative regulation of cellular metabolic process macromolecule catabolic process cellular catabolic process regulation of glycogen catabolic process glycogen catabolic process negative regulation of cellular process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of carbohydrate catabolic process glucan catabolic process negative regulation of metabolic process regulation of catabolic process negative regulation of glycogen catabolic process polysaccharide catabolic process regulation of cellular catabolic process	glycogen granule intracellular anatomical structure cytoplasm cellular anatomical entity phosphatase complex protein-containing complex protein phosphatase type 1 complex catalytic complex protein serine/threonine phosphatase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR030682	Protein phosphatase 1 regulatory subunit 3B	Family
A	IPR050782	Protein phosphatase 1 regulatory subunit 3	Family
A	IPR038175	CBM21 domain superfamily	Homologous Superfamily
A	IPR017434	Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa	Family
A	IPR005036	CBM21 (carbohydrate binding type-21) domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q86XI6	Liver Cirrhosis, Experimental pilocytic astrocytoma spina bifida ulcerative colitis adenoma atypical teratoid rhabdoid tumor glioblastoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer subependymal giant cell astrocytoma adrenal cortex carcinoma chronic obstructive pulmonary disease interstitial cystitis Liver Cirrhosis, Experimental pilocytic astrocytoma spina bifida ulcerative colitis adenoma atypical teratoid rhabdoid tumor glioblastoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer subependymal giant cell astrocytoma adrenal cortex carcinoma chronic obstructive pulmonary disease interstitial cystitis malignant ependymoma myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis tuberculosis Alzheimer disease cystic fibrosis large cell medulloblastoma malignant glioma osteoarthritis pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.