2H9C

Native Crystal Structure of the Isochorismate-Pyruvate Lyase from Pseudomonas aeruginosa

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2h9ca_	All alpha proteins	Chorismate mutase II	Chorismate mutase II	Dimeric chorismate mutase	Salicylate biosynthesis protein PchB	(Pseudomonas aeruginosa PAO1 ) [TaxId: 208964 ],	SCOPe (2.08)
B	d2h9cb_	All alpha proteins	Chorismate mutase II	Chorismate mutase II	Dimeric chorismate mutase	Salicylate biosynthesis protein PchB	(Pseudomonas aeruginosa PAO1 ) [TaxId: 208964 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	chorismate mutase ii	8042202	3001645	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	chorismate mutase ii	8042202	3001645	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CM_2	e2h9cA1	A: alpha bundles	X: Chorismate mutase II (From Topology)	H: Chorismate mutase II (From Topology)	T: Chorismate mutase II	F: CM_2	ECOD (1.6)
B	CM_2	e2h9cB1	A: alpha bundles	X: Chorismate mutase II (From Topology)	H: Chorismate mutase II (From Topology)	T: Chorismate mutase II	F: CM_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.59.10	Mainly Alpha	Up-down Bundle	Chorismate Mutase Domain, subunit A	Chorismate mutase	CATH (4.3.0)
B	1.20.59.10	Mainly Alpha	Up-down Bundle	Chorismate Mutase Domain, subunit A	Chorismate mutase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01817	Chorismate mutase type II (CM_2)	Chorismate mutase type II	Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Salicylate biosynthesis protein pchB	isomerase activity chorismate mutase activity catalytic activity intramolecular transferase activity isochorismate pyruvate lyase activity lyase activity carbon-oxygen lyase activity	monocarboxylic acid biosynthetic process benzene-containing compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process salicylic acid biosynthetic process cellular metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process salicylic acid metabolic process carboxylic acid biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process monocarboxylic acid biosynthetic process benzene-containing compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process salicylic acid biosynthetic process cellular metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process salicylic acid metabolic process carboxylic acid biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process phenol-containing compound biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process pyochelin metabolic process secondary metabolic process siderophore biosynthetic process siderophore metabolic process secondary metabolite biosynthetic process sulfur compound metabolic process sulfur compound biosynthetic process peptide biosynthetic process pyochelin biosynthetic process nonribosomal peptide biosynthetic process peptide metabolic process dicarboxylic acid metabolic process chorismate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036979	Chorismate mutase domain superfamily	Homologous Superfamily
A, B	IPR051331	Chorismate mutase-related enzymes	Family
A, B	IPR002701	Chorismate mutase II, prokaryotic-type	Domain
A, B	IPR008241	Salicylate biosynthesis protein PchB	Family
A, B	IPR036263	Chorismate mutase type II superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.