2NP5

Crystal structure of a transcriptional regulator (RHA1_ro04179) from Rhodococcus sp. Rha1.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2np5b1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Tetracyclin repressor-like, N-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)
B	d2np5b2	All alpha proteins	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)
C	d2np5c1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Tetracyclin repressor-like, N-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)
C	d2np5c2	All alpha proteins	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)
D	d2np5d1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Tetracyclin repressor-like, N-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)
D	d2np5d2	All alpha proteins	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)
A	d2np5a1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Tetracyclin repressor-like, N-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)
A	d2np5a2	All alpha proteins	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Tetracyclin repressor-like, C-terminal domain	Transcriptional regulator RHA1_ro04179	(Rhodococcus jostii RHA1 ) [TaxId: 101510 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Homeodomain-like	8056427	3000001	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	TetR C-terminal domain-like	8056428	3000086	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TetR C-terminal domain-like	8056428	3000086	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Homeodomain-like	8056427	3000001	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	TetR C-terminal domain-like	8056428	3000086	SCOP2B (2022-06-29)
A	SCOP2 Family	Tetracyclin repressor-like	8056426	4000333	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	TetR C-terminal domain-like	8056428	3000086	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Homeodomain-like	8056427	3000001	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	TetR_N_2	e2np5B1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N_2	ECOD (1.6)
B	TetR_C_6	e2np5B2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_6	ECOD (1.6)
C	TetR_N_2	e2np5C1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N_2	ECOD (1.6)
C	TetR_C_6	e2np5C2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_6	ECOD (1.6)
D	TetR_N_2	e2np5D1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N_2	ECOD (1.6)
D	TetR_C_6	e2np5D2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_6	ECOD (1.6)
A	TetR_N_2	e2np5A1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: TetR_N_2	ECOD (1.6)
A	TetR_C_6	e2np5A2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: TetR_C_6	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
C	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
D	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
A	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13977	BetI-type transcriptional repressor, C-terminal (TetR_C_6)	BetI-type transcriptional repressor, C-terminal	This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins ...	This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity [1]. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Transcriptional regulator	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription regulator activity DNA-binding transcription factor activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR009057	Homedomain-like superfamily	Homologous Superfamily
A, B, C, D	IPR050109	HTH-type, TetR-like transcriptional regulator	Family
A, B, C, D	IPR001647	DNA-binding HTH domain, TetR-type	Domain
A, B, C, D	IPR036271	Tetracyclin repressor-like, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR039538	BetI-type transcriptional repressor, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.