Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Cd2ny3c1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2ny3c2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2ny3d1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2ny3d2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad2ny3a1 Alpha and beta proteins (a+b) gp120 core gp120 core gp120 core gp120 core (Human immunodeficiency virus 1 ) [TaxId: 11676 ], SCOPe (2.08)
Bd2ny3b1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) CD4 V-set domains human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2ny3b2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C2 set domains CD4 C2-set domains human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054493 3000071 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054739 3000071 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
CC1-set_4e2ny3C2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
CV-sete2ny3C1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
DV-set_8e2ny3D1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
DC1-set_1e2ny3D2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
AGP120_3rde2ny3A1 A: a+b two layersX: Ribosomal protein L31e-likeH: Ribosomal protein L31e/gp120 outer domain (From Topology)T: Ribosomal protein L31e/gp120 outer domainF: GP120_3rdECOD (1.6)
AGP120_1ste2ny3A2 A: a+b two layersX: gp120 inner domain (From Topology)H: gp120 inner domain (From Topology)T: gp120 inner domainF: GP120_1stECOD (1.6)
BC2-sete2ny3B2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C2-setECOD (1.6)
BV-set_9e2ny3B1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_9ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
C2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
D2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
A2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120 Chain GCATH (4.3.0)
B2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
17B mAb, anti-gp120 [HIV-1] L-KAPPA Homo sapiens (human) IGKV3-15*01, IGKV3D-15*01, IGKJ2*01, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202445-0)
17B mAb, anti-gp120 [HIV-1] VH-CH1 Homo sapiens (human) IGHV1-69*02, IGHV1-69*04, IGHV1-69*08, IGHV1-69*09, IGHJ1*01, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202445-0)
CD4 1V-1C-LIKE Homo sapiens (human) CD4 V-LIKE-DOMAIN V-LIKE, C-LIKE-DOMAIN C-LIKE RPI 1V-1C-LIKE IMGT (202445-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
Light ChainIGKV3 Kappaenvelope glycoprotein gp120SAbDab (2024-11-15)
Heavy ChainIGHV1 -envelope glycoprotein gp120SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
PF00516Envelope glycoprotein GP120 (GP120)Envelope glycoprotein GP120- Family
PF05790Immunoglobulin C2-set domain (C2-set)Immunoglobulin C2-set domain- Domain
PF00047Immunoglobulin domain (ig)Immunoglobulin domainMembers of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prot ...Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ANTIBODY 17B, LIGHT CHAIN- -
ANTIBODY 17B, HEAVY CHAIN-
ENVELOPE GLYCOPROTEIN GP120
T-cell surface glycoprotein CD4

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR003597Immunoglobulin C1-setDomain
IPR050150Immunoglobulin Variable Light ChainFamily
IPR013783Immunoglobulin-like foldHomologous Superfamily
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
IPR013106Immunoglobulin V-set domainDomain
IPR003599Immunoglobulin domain subtypeDomain
IPR007110Immunoglobulin-like domainDomain
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
IPR003597Immunoglobulin C1-setDomain
IPR013783Immunoglobulin-like foldHomologous Superfamily
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
IPR013106Immunoglobulin V-set domainDomain
IPR003599Immunoglobulin domain subtypeDomain
IPR007110Immunoglobulin-like domainDomain
IPR050380Immune Recognition and Response ModulatorsFamily
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
IPR000777Human immunodeficiency virus 1, envelope glycoprotein Gp120Domain
IPR036377Gp120 core superfamilyHomologous Superfamily
IPR000328Retroviral envelope protein GP41-likeDomain
IPR021963T cell CD4 receptor C-terminal regionDomain
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
IPR013106Immunoglobulin V-set domainDomain
IPR000973T-cell surface antigen CD4Family
IPR003599Immunoglobulin domain subtypeDomain
IPR008424Immunoglobulin C2-setDomain
IPR013151Immunoglobulin-like beta-sandwich domainDomain
IPR015274CD4, extracellularDomain
IPR013783Immunoglobulin-like foldHomologous Superfamily
IPR007110Immunoglobulin-like domainDomain
IPR003598Immunoglobulin subtype 2Domain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP01730