Annotations: 2OBE

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2obea1	All beta proteins	Nucleoplasmin-like/VP (viral coat and capsid proteins)	Group II dsDNA viruses VP	automated matches	automated matches	(Simian adenovirus 25 ) [TaxId: 175567 ],	SCOPe (2.08)
B	d2obeb1	All beta proteins	Nucleoplasmin-like/VP (viral coat and capsid proteins)	Group II dsDNA viruses VP	automated matches	automated matches	(Simian adenovirus 25 ) [TaxId: 175567 ],	SCOPe (2.08)
C	d2obec1	All beta proteins	Nucleoplasmin-like/VP (viral coat and capsid proteins)	Group II dsDNA viruses VP	automated matches	automated matches	(Simian adenovirus 25 ) [TaxId: 175567 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adeno_hexon	e2obeA1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
A	Adeno_hexon_C	e2obeA2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
B	Adeno_hexon	e2obeB1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
B	Adeno_hexon_C	e2obeB2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
C	Adeno_hexon	e2obeC1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
C	Adeno_hexon_C	e2obeC2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.249.10	Alpha Beta	Alpha-Beta Complex	Hexon Major Viral Coat Protein	domain 3	CATH (4.3.0)
A	2.170.9.10	Mainly Beta	Beta Complex	Adenovirus Type 2 Hexon	domain 1	CATH (4.3.0)
A	3.90.39.10	Alpha Beta	Alpha-Beta Complex	Hexon Major Viral Coat Protein	domain 2	CATH (4.3.0)
A	2.70.9.10	Mainly Beta	Distorted Sandwich	Adenovirus Type 2 Hexon	domain 4	CATH (4.3.0)
B	3.90.249.10	Alpha Beta	Alpha-Beta Complex	Hexon Major Viral Coat Protein	domain 3	CATH (4.3.0)
B	2.170.9.10	Mainly Beta	Beta Complex	Adenovirus Type 2 Hexon	domain 1	CATH (4.3.0)
B	3.90.39.10	Alpha Beta	Alpha-Beta Complex	Hexon Major Viral Coat Protein	domain 2	CATH (4.3.0)
B	2.70.9.10	Mainly Beta	Distorted Sandwich	Adenovirus Type 2 Hexon	domain 4	CATH (4.3.0)
C	3.90.249.10	Alpha Beta	Alpha-Beta Complex	Hexon Major Viral Coat Protein	domain 3	CATH (4.3.0)
C	2.170.9.10	Mainly Beta	Beta Complex	Adenovirus Type 2 Hexon	domain 1	CATH (4.3.0)
C	3.90.39.10	Alpha Beta	Alpha-Beta Complex	Hexon Major Viral Coat Protein	domain 2	CATH (4.3.0)
C	2.70.9.10	Mainly Beta	Distorted Sandwich	Adenovirus Type 2 Hexon	domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01065	Hexon, adenovirus major coat protein, N-terminal domain (Adeno_hexon)	Hexon, adenovirus major coat protein, N-terminal domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polype ...	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	Domain
A, B, C	PF03678	Hexon, adenovirus major coat protein, C-terminal domain (Adeno_hexon_C)	Hexon, adenovirus major coat protein, C-terminal domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polype ...	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Hexon protein	structural molecule activity	microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host biological process involved in interaction with host biological process involved in symbiotic interaction	host cellular component cellular anatomical structure host cell host intracellular membrane-bounded organelle host intracellular part host cell part host intracellular region host cell nucleus host intracellular organelle viral capsid icosahedral viral capsid virion component T=25 icosahedral viral capsid

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR044942	Adenovirus Pll, hexon, subdomain 2	Homologous Superfamily
A, B, C	IPR016107	Adenovirus Pll, hexon, N-terminal	Domain
A, B, C	IPR016108	Adenovirus Pll, hexon, C-terminal	Domain
A, B, C	IPR016112	Group II dsDNA virus coat/capsid protein	Homologous Superfamily
A, B, C	IPR037542	Adenovirus hexon protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.