Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2ocpa_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2ocpc_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2ocpb_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2ocpd_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed2ocpe_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd2ocpf_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Gd2ocpg_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Hd2ocph_ Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases Nucleotide and nucleoside kinases Deoxyguanosine kinase human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyDeoxynucleoside kinase-like 8058409 4004030 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2 (2022-06-29)
CSCOP2B SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyP-loop nucleotide/nucleoside kinase-like 8058410 3002021 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AdNKe2ocpA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)
CdNKe2ocpC1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)
BdNKe2ocpB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)
DdNKe2ocpD1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)
EdNKe2ocpE1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)
FdNKe2ocpF1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)
GdNKe2ocpG1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)
HdNKe2ocpH1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: dNKECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF01712Deoxynucleoside kinase (dNK)Deoxynucleoside kinaseThis family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyse the prod ...This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyse the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Deoxyguanosine kinase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR002624Deoxynucleoside kinaseFamily
A, B, C, D, E
IPR050566Deoxyribonucleoside KinaseFamily
A, B, C, D, E
IPR031314Deoxynucleoside kinase domainDomain
A, B, C, D, E
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
deoxyguanosine kinase  M-CSA #615

Deoxyribonucleoside kinases such as deoxyguanoside kinase (dGK) phosphorylate deoxyribonucleosides. The human form is highly specific for purine substrates. Deoxynucleoside kinases are key targets in chemotherapy of cancer as they are recquired to activate nucleoside analogues by phosphorylation. dGK is involved in the regulation of dGTP and dATP pools, and may have a role in apoptosis.

Defined by 2 residues: GLU:A-34 [auth A-70]ARG:A-106 [auth A-142]
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