2OCP
Crystal Structure of Human Deoxyguanosine Kinase
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Structure Motif: Primary M-CSA Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | Deoxynucleoside kinase-like | 8058409 | 4004030 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2 (2022-06-29) |
B | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2B (2022-06-29) |
H | SCOP2B Superfamily | P-loop nucleotide/nucleoside kinase-like | 8058410 | 3002021 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | dNK | e2ocpA1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
B | dNK | e2ocpB1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
C | dNK | e2ocpC1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
D | dNK | e2ocpD1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
E | dNK | e2ocpE1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
F | dNK | e2ocpF1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
G | dNK | e2ocpG1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
H | dNK | e2ocpH1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: dNK | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01712 | Deoxynucleoside kinase (dNK) | Deoxynucleoside kinase | This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyse the prod ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Pharos: Disease Associations Pharos Homepage Annotation
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
Chains | Enzyme Name | Description | Catalytic Residues |
---|---|---|---|
deoxyguanosine kinase M-CSA #615 | Deoxyribonucleoside kinases such as deoxyguanoside kinase (dGK) phosphorylate deoxyribonucleosides. The human form is highly specific for purine substrates. Deoxynucleoside kinases are key targets in chemotherapy of cancer as they are recquired to activate nucleoside analogues by phosphorylation. dGK is involved in the regulation of dGTP and dATP pools, and may have a role in apoptosis. | Defined by 2 residues: GLU:A-34 [auth A-70]ARG:A-106 [auth A-142] | EC: 2.7.1.113 (PDB Primary Data) EC: 2.7.1.76 (UniProt) |