2OX8

Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ox8a_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ox8b_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2ox8d_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2ox8c_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	C-type lectin domain	8065471	4002453	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-type lectin-like	8065472	3001261	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	C-type lectin-like	8065472	3001261	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	C-type lectin-like	8065472	3001261	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C-type lectin-like	8065472	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lectin_C	e2ox8A1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
B	Lectin_C	e2ox8B1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
D	Lectin_C	e2ox8D1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
C	Lectin_C	e2ox8C1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
B	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
D	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
C	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Scavenger receptor with C-type lectin type I	binding galactose binding monosaccharide binding carbohydrate binding small molecule binding molecular transducer activity pattern recognition receptor activity signaling receptor activity cargo receptor activity scavenger receptor activity lipoprotein particle binding protein-containing complex binding protein-lipid complex binding low-density lipoprotein particle binding binding galactose binding monosaccharide binding carbohydrate binding small molecule binding molecular transducer activity pattern recognition receptor activity signaling receptor activity cargo receptor activity scavenger receptor activity lipoprotein particle binding protein-containing complex binding protein-lipid complex binding low-density lipoprotein particle binding cation binding ion binding metal ion binding	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to nitrogen compound biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to nitrogen compound cellular response to stimulus cellular response to dsRNA cellular response to exogenous dsRNA cellular response to organic cyclic compound response to dsRNA response to nitrogen compound response to exogenous dsRNA cellular response to chemical stimulus response to chemical cellular process response to organic cyclic compound defense response to bacterium response to bacterium regulation of biological process regulation of cellular process signaling biological regulation response to oxygen-containing compound cellular response to oxygen-containing compound cell communication cellular response to carbohydrate stimulus response to carbohydrate signal transduction carbohydrate mediated signaling plasma membrane raft organization membrane organization cellular component organization plasma membrane organization cellular component organization or biogenesis membrane raft organization endomembrane system organization positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway intracellular signal transduction immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway regulation of innate immune response regulation of response to stimulus positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway positive regulation of biological process positive regulation of response to stimulus endolysosomal toll-like receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress positive regulation of innate immune response toll-like receptor 3 signaling pathway phagocytosis, recognition localization import into cell transport phagocytosis cell recognition endocytosis establishment of localization vesicle-mediated transport	protein-containing complex collagen trimer cellular anatomical structure membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle protein-containing complex collagen trimer cellular anatomical structure membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR008160	Collagen triple helix repeat	Repeat
A, B, C, D	IPR016187	C-type lectin fold	Homologous Superfamily
A, B, C, D	IPR033989	CD209-like, C-type lectin-like domain	Domain
A, B, C, D	IPR001304	C-type lectin-like	Domain
A, B, C, D	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B, C, D	IPR018378	C-type lectin, conserved site	Conserved Site
A, B, C, D	IPR050111	C-type lectin and snaclec domain-containing protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q5KU26	Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous carcinoma substance-related disorder atopic eczema drug dependence Duchenne muscular dystrophy lung carcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma substance dependence cystic fibrosis facioscapulohumeral muscular dystrophy lung adenocarcinoma Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous carcinoma substance-related disorder atopic eczema drug dependence Duchenne muscular dystrophy lung carcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma substance dependence cystic fibrosis facioscapulohumeral muscular dystrophy lung adenocarcinoma malignant colon neoplasm non-small cell lung carcinoma ovarian cancer pilocytic astrocytoma substance abuse juvenile dermatomyositis lung cancer malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.