Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH
External Resource: Annotation
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
A | SCOP2B Superfamily | NAD(P)-linked oxidoreductase | 8062005 | 3000288 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | NAD(P)-linked oxidoreductase | 8062005 | 3000288 | SCOP2B (2022-06-29) |
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
A | Aldo_ket_red | e2p5nA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Aldo_ket_red | ECOD (1.6) |
B | Aldo_ket_red | e2p5nB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Aldo_ket_red | ECOD (1.6) |
Chains | Accession | Name | Description | Comments | Source |
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| PF00248 | Aldo/keto reductase family (Aldo_ket_red) | Aldo/keto reductase family | This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2]. | Domain |
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
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| Aldo-keto reductase family 1, member C21 | - NADP+ binding
- binding
- nucleotide binding
- nucleoside phosphate binding
- ion binding
- purine nucleotide binding
- organic cyclic compound binding
- anion binding
- adenyl nucleotide binding
- heterocyclic compound binding
- NADP binding
- small molecule binding
- lithocholic acid binding
- organic acid binding
- bile acid binding
- steroid binding
- lipid binding
- carboxylic acid binding
- monocarboxylic acid binding
- NADPH binding
- aldo-keto reductase (NADPH) activity
- alcohol dehydrogenase [NAD(P)+] activity
- oxidoreductase activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- oxidoreductase activity, acting on CH-OH group of donors
- catalytic activity
- steroid dehydrogenase activity
- 17-beta-ketosteroid reductase (NADPH) activity
- steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- alcohol dehydrogenase (NADP+) activity
- aldose reductase (NADPH) activity
- androsterone dehydrogenase activity
- monooxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- ketosteroid monooxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
- 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
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