2Q42

Ensemble refinement of the protein crystal structure of glyoxalase II from Arabidopsis thaliana gene At2g31350

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2q42a2	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	Glyoxalase II (hydroxyacylglutathione hydrolase)	Glyoxalase II (hydroxyacylglutathione hydrolase)	thale cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
A	d2q42a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	thale cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
B	d2q42b2	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	Glyoxalase II (hydroxyacylglutathione hydrolase)	Glyoxalase II (hydroxyacylglutathione hydrolase)	thale cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
B	d2q42b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	thale cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metallo-hydrolase/oxidoreductase	8044001	3001057	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metallo-hydrolase/oxidoreductase	8044001	3001057	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lactamase_B	e2q42A1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B	ECOD (1.6)
B	Lactamase_B	e2q42B1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
B	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16123	Hydroxyacylglutathione hydrolase C-terminus (HAGH_C)	Hydroxyacylglutathione hydrolase C-terminus	-	Family
A, B	PF00753	Metallo-beta-lactamase superfamily (Lactamase_B)	Metallo-beta-lactamase superfamily	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Putative hydroxyacylglutathione hydrolase 2	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding hydroxyacylglutathione hydrolase activity hydrolase activity, acting on ester bonds thiolester hydrolase activity hydrolase activity catalytic activity iron ion binding	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione catabolic process oxoacid metabolic process cellular metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process methylglyoxal catabolic process organic acid metabolic process methylglyoxal catabolic process to lactate lactate metabolic process cellular catabolic process cellular ketone metabolic process cellular aldehyde metabolic process ketone catabolic process methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione catabolic process oxoacid metabolic process cellular metabolic process organic hydroxy compound metabolic process carboxylic acid metabolic process methylglyoxal catabolic process organic acid metabolic process methylglyoxal catabolic process to lactate lactate metabolic process cellular catabolic process cellular ketone metabolic process cellular aldehyde metabolic process ketone catabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process aldehyde catabolic process small molecule catabolic process methylglyoxal metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR032282	Hydroxyacylglutathione hydrolase, C-terminal domain	Domain
A, B	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
A, B	IPR017782	Hydroxyacylglutathione hydrolase	Family
A, B	IPR001279	Metallo-beta-lactamase	Domain
A, B	IPR050110	Glyoxalase II family hydroxyacylglutathione hydrolases	Family
A, B	IPR035680	Hydroxyacylglutathione hydrolase, MBL domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.