Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyZn-dependent exopeptidases 8034373 3000662 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyZn-dependent exopeptidases 8034373 3000662 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAstE_AspA_C_1e2q51A3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: Succinylglutamate desuccinylase / Aspartoacylase C-terminal domain (From Topology)T: Succinylglutamate desuccinylase / Aspartoacylase C-terminal domainF: AstE_AspA_C_1ECOD (1.6)
AAstE_AspA_Ne2q51A2 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: AstE_AspA_NECOD (1.6)
BAstE_AspA_C_1e2q51B3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: Succinylglutamate desuccinylase / Aspartoacylase C-terminal domain (From Topology)T: Succinylglutamate desuccinylase / Aspartoacylase C-terminal domainF: AstE_AspA_C_1ECOD (1.6)
BAstE_AspA_Ne2q51B2 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: AstE_AspA_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
A2.20.25.160 Mainly Beta Single Sheet N-terminal domain of TfIIb CATH (4.3.0)
B3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
B2.20.25.160 Mainly Beta Single Sheet N-terminal domain of TfIIb CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF04952Succinylglutamate desuccinylase / Aspartoacylase family (AstE_AspA)Succinylglutamate desuccinylase / Aspartoacylase familyThis family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate ...This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease disease [1]. This family is probably structurally related to Pfam:PF00246 (Bateman A pers. obs.).
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Aspartoacylase