Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8041600 3001790 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTK C-terminal domain-like 8041601 3000424 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8041598 3001790 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8041600 3001790 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8041598 3001790 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyTK C-terminal domain-like 8041601 3000424 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BTransketolase_C_1e2qtaB3 A: a/b three-layered sandwichesX: TK C-terminal domain-like (From Topology)H: TK C-terminal domain-like (From Topology)T: TK C-terminal domain-likeF: Transketolase_C_1ECOD (1.6)
BTransketolase_Ne2qtaB2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: Transketolase_NECOD (1.6)
BaceEe2qtaB4 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: aceEECOD (1.6)
ATransketolase_C_1e2qtaA3 A: a/b three-layered sandwichesX: TK C-terminal domain-like (From Topology)H: TK C-terminal domain-like (From Topology)T: TK C-terminal domain-likeF: Transketolase_C_1ECOD (1.6)
ATransketolase_Ne2qtaA4 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: Transketolase_NECOD (1.6)
AaceEe2qtaA2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: aceEECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF17831Pyruvate dehydrogenase E1 component middle domain (PDH_E1_M)Pyruvate dehydrogenase E1 component middle domainThis entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component [1].Domain
A, B
PF00456Transketolase, thiamine diphosphate binding domain (Transketolase_N)Transketolase, thiamine diphosphate binding domainThis family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common ...This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Domain
A, B
PF22613Transketolase-like TK C-terminal domain (Transketolase_C_1)Transketolase-like TK C-terminal domainThis entry represents the C-terminal domain found in transketolase and transketolase-like enzymes [1-5], such as pyruvate dehydrogenase E1 component (OPD1) [4].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Pyruvate dehydrogenase E1 component