Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyPilZ domain-like 8024441 4001865 SCOP2 (2022-06-29)
ASCOP2 FamilyPilZ domain-associated domain 8024443 4001875 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyPilZ domain-like 8036820 3000480 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyPilZ domain-like 8036822 3000480 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyPilZ domain-like 8036822 3000480 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPilZ domain-like 8036820 3000480 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APilZe2rdeA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: PilZECOD (1.6)
AYcgR_2e2rdeA2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: YcgR_2ECOD (1.6)
BPilZe2rdeB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: PilZECOD (1.6)
BYcgR_2e2rdeB2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: YcgR_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.30.110.10 Mainly Beta Roll Pnp Oxidase Chain ACATH (4.3.0)
A2.40.10.220 Mainly Beta Beta Barrel Thrombin, subunit H predicted glycosyltransferase like domainsCATH (4.3.0)
B2.30.110.10 Mainly Beta Roll Pnp Oxidase Chain ACATH (4.3.0)
B2.40.10.220 Mainly Beta Beta Barrel Thrombin, subunit H predicted glycosyltransferase like domainsCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF07238PilZ domain (PilZ)PilZ domainPilZ is a c-di-GMP binding domain [3] found in widespread cytoplasmic receptors, which is involved in regulation of motility, biofilm formation and virulence of many bacterial pathogens. This domain binds c-di-GMP through RXXXR and [D/N]hSXXG motifs, ...PilZ is a c-di-GMP binding domain [3] found in widespread cytoplasmic receptors, which is involved in regulation of motility, biofilm formation and virulence of many bacterial pathogens. This domain binds c-di-GMP through RXXXR and [D/N]hSXXG motifs, however, some PilZ domains lack these motifs and do not bind c-di-GMP [6]. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias [5]. This is the canonical PilZ domain whose structure consists of six beta-strands that form a beta barrel, followed by a long C-terminal alpha-helix [6].
Domain
A, B
PF12945Flagellar protein YcgR (PilZNR)Flagellar protein YcgR- Family