2RLB

Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to M6P in absence of Mn

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2rlba_	All beta proteins	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2rlbb_	All beta proteins	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8036941	3001527	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Mannose 6-phosphate receptor domain	8036941	3001527	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Man-6-P_recep	e2rlbA1	A: beta barrels	X: Mannose 6-phosphate receptor domain (From Topology)	H: Mannose 6-phosphate receptor domain (From Topology)	T: Mannose 6-phosphate receptor domain	F: Man-6-P_recep	ECOD (1.6)
B	Man-6-P_recep	e2rlbB1	A: beta barrels	X: Mannose 6-phosphate receptor domain (From Topology)	H: Mannose 6-phosphate receptor domain (From Topology)	T: Mannose 6-phosphate receptor domain	F: Man-6-P_recep	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.130.10	Mainly Beta	Distorted Sandwich	Cation-dependent Mannose-6-phosphate Receptor	Chain A	CATH (4.3.0)
B	2.70.130.10	Mainly Beta	Distorted Sandwich	Cation-dependent Mannose-6-phosphate Receptor	Chain A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cation-dependent mannose-6-phosphate receptor	protein binding binding protein domain specific binding	protein localization cellular localization establishment of protein localization nitrogen compound transport transport protein targeting establishment of protein localization to vacuole lysosomal transport localization protein targeting to lysosome establishment of localization in cell cellular macromolecule localization protein targeting to vacuole intracellular transport protein localization cellular localization establishment of protein localization nitrogen compound transport transport protein targeting establishment of protein localization to vacuole lysosomal transport localization protein targeting to lysosome establishment of localization in cell cellular macromolecule localization protein targeting to vacuole intracellular transport protein localization to vacuole establishment of localization protein localization to lysosome establishment of protein localization to organelle protein transport protein localization to organelle macromolecule localization vacuolar transport cellular process intracellular protein transport	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome Golgi apparatus subcompartment Golgi apparatus organelle subcompartment endomembrane system trans-Golgi network endosome intracellular vesicle cytoplasmic vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR009011	Mannose-6-phosphate receptor binding domain superfamily	Homologous Superfamily
A, B	IPR044865	MRH domain	Domain
A, B	IPR028927	Mannose-6-phosphate receptor	Family
A, B	IPR000296	Cation-dependent mannose-6-phosphate receptor	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.