2SLI

LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC, THE REACTION PRODUCT

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2slia1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Leech intramolecular trans-sialidase, N-terminal domain	Leech intramolecular trans-sialidase, N-terminal domain	North American leech (Macrobdella decora ) [TaxId: 6405 ],	SCOPe (2.08)
A	d2slia2	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Leech intramolecular trans-sialidase, C-terminal domain	North American leech (Macrobdella decora ) [TaxId: 6405 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Trans-sialidase N-terminal domain-like	8029074	4002727	SCOP2 (2022-06-29)
A	SCOP2 Family	Trans-sialidase catalytic domain-like	8030456	4006603	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Concanavalin A-like lectins/glucanases	8041453	3000120	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Sialidases	8042835	3001607	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Laminin_G_3	e2sliA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_3	ECOD (1.6)
A	BNR_2	e2sliA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: BNR_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
A	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
A	2.40.220.10	Mainly Beta	Beta Barrel	Intramolecular trans-sialidase	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13088	BNR repeat-like domain (BNR_2)	BNR repeat-like domain	-	Repeat
A	PF02973	Sialidase, N-terminal domain (Sialidase)	Sialidase, N-terminal domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	INTRAMOLECULAR TRANS-SIALIDASE	anhydrosialidase activity lyase activity carbon-oxygen lyase activity, acting on polysaccharides catalytic activity carbon-oxygen lyase activity hydrolase activity, acting on glycosyl bonds alpha-sialidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity exo-alpha-sialidase activity	carbohydrate metabolic process primary metabolic process metabolic process cellular process	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR004124	Glycoside hydrolase, family 33, N-terminal	Domain
A	IPR011040	Sialidase	Domain
A	IPR026856	Sialidase family	Family
A	IPR023364	Trans-sialidase, domain 3	Homologous Superfamily
A	IPR036278	Sialidase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.