Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2uyya2 All alpha proteins 6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad2uyya1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2uyyb2 All alpha proteins 6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2uyyb1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2uyyc2 All alpha proteins 6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2uyyc1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2uyyd2 All alpha proteins 6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2uyyd1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ANAD_binding_11e2uyyA3 A: alpha arraysX: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)T: 6-phosphogluconate dehydrogenase C-terminal domain-likeF: NAD_binding_11ECOD (1.6)
ANAD_binding_2e2uyyA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: NAD_binding_2ECOD (1.6)
BNAD_binding_11e2uyyB1 A: alpha arraysX: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)T: 6-phosphogluconate dehydrogenase C-terminal domain-likeF: NAD_binding_11ECOD (1.6)
BNAD_binding_2e2uyyB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: NAD_binding_2ECOD (1.6)
CNAD_binding_11e2uyyC3 A: alpha arraysX: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)T: 6-phosphogluconate dehydrogenase C-terminal domain-likeF: NAD_binding_11ECOD (1.6)
CNAD_binding_2e2uyyC2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: NAD_binding_2ECOD (1.6)
DNAD_binding_11e2uyyD3 A: alpha arraysX: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)T: 6-phosphogluconate dehydrogenase C-terminal domain-likeF: NAD_binding_11ECOD (1.6)
DNAD_binding_2e2uyyD2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: NAD_binding_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF14833NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase (NAD_binding_11)NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent a ...3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts an alpha helical structure [1].
Domain
A, B, C, D
PF03446NAD binding domain of 6-phosphogluconate dehydrogenase (NAD_binding_2)NAD binding domain of 6-phosphogluconate dehydrogenaseThe NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
N-PAC PROTEIN