2V43

Crystal structure of RseB: a sensor for periplasmic stress response in E. coli

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	LolA-like	8054207	3001964	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	TM1622-like	8054208	3001463	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	TM1622-like	8054208	3001463	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	LolA-like	8054207	3001964	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	LolA-like	8054207	3001964	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TM1622-like	8054208	3001463	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	MucB_RseB	e2v43B3	A: beta meanders	X: Lipoprotein localization factors LolAB	H: Lipoprotein localization factors LolAB (From Topology)	T: Lipoprotein localization factors LolAB	F: MucB_RseB	ECOD (1.6)
B	MucB_RseB_C	e2v43B2	A: a+b three layers	X: Mog1p/PsbP-like	H: C-terminal domain in sigma-E factor regulatory protein rseB (From Topology)	T: C-terminal domain in sigma-E factor regulatory protein rseB	F: MucB_RseB_C	ECOD (1.6)
A	MucB_RseB	e2v43A3	A: beta meanders	X: Lipoprotein localization factors LolAB	H: Lipoprotein localization factors LolAB (From Topology)	T: Lipoprotein localization factors LolAB	F: MucB_RseB	ECOD (1.6)
A	MucB_RseB_C	e2v43A2	A: a+b three layers	X: Mog1p/PsbP-like	H: C-terminal domain in sigma-E factor regulatory protein rseB (From Topology)	T: C-terminal domain in sigma-E factor regulatory protein rseB	F: MucB_RseB_C	ECOD (1.6)
C	MucB_RseB	e2v43C3	A: beta meanders	X: Lipoprotein localization factors LolAB	H: Lipoprotein localization factors LolAB (From Topology)	T: Lipoprotein localization factors LolAB	F: MucB_RseB	ECOD (1.6)
C	MucB_RseB_C	e2v43C2	A: a+b three layers	X: Mog1p/PsbP-like	H: C-terminal domain in sigma-E factor regulatory protein rseB (From Topology)	T: C-terminal domain in sigma-E factor regulatory protein rseB	F: MucB_RseB_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.50.20.10	Mainly Beta	Clam	outer membrane lipoprotein receptor (LolB), chain A	Lipoprotein localisation LolA/LolB/LppX	CATH (4.3.0)
A	2.50.20.10	Mainly Beta	Clam	outer membrane lipoprotein receptor (LolB), chain A	Lipoprotein localisation LolA/LolB/LppX	CATH (4.3.0)
C	2.50.20.10	Mainly Beta	Clam	outer membrane lipoprotein receptor (LolB), chain A	Lipoprotein localisation LolA/LolB/LppX	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF03888	MucB/RseB N-terminal domain (MucB_RseB)	MucB/RseB N-terminal domain	Members of this family are regulators of the anti-sigma E protein RseD.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	SIGMA-E FACTOR REGULATORY PROTEIN RSEB	protein binding binding antisigma factor binding lipid binding identical protein binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process regulation of carbohydrate metabolic process regulation of protein stability regulation of biological quality protein stabilization	protein-containing complex sigma factor antagonist complex transcription regulator complex cell periphery cellular anatomical structure plasma membrane membrane outer membrane-bounded periplasmic space cell envelope periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR005588	MucB/RseB	Family
A, B, C	IPR033436	MucB/RseB, C-terminal	Domain
A, B, C	IPR033434	MucB/RseB, N-terminal	Domain
A, B, C	IPR038484	MucB/RseB, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.