Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AACR_tran_4the2v50A1 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
AACR_tran_1ste2v50A3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
AACR_tran_5the2v50A5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
AACR_tran_3rde2v50A4 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
AACR_tran_6the2v50A6 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
AACR_tran_2nde2v50A7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
AACR_tran_6th_1e2v50A8 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
CACR_tran_4the2v50C15 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
CACR_tran_1ste2v50C13 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
CACR_tran_5the2v50C9 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
CACR_tran_3rde2v50C16 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
CACR_tran_6the2v50C14 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
CACR_tran_2nde2v50C11 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
CACR_tran_6th_1e2v50C10 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
DACR_tran_4the2v50D23 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
DACR_tran_1ste2v50D21 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
DACR_tran_5the2v50D17 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
DACR_tran_3rde2v50D24 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
DACR_tran_6the2v50D22 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
DACR_tran_2nde2v50D19 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
DACR_tran_6th_1e2v50D18 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
EACR_tran_4the2v50E15 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
EACR_tran_1ste2v50E13 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
EACR_tran_5the2v50E9 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
EACR_tran_3rde2v50E16 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
EACR_tran_6the2v50E14 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
EACR_tran_2nde2v50E11 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
EACR_tran_6th_1e2v50E10 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
FACR_tran_4the2v50F15 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
FACR_tran_1ste2v50F13 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
FACR_tran_5the2v50F9 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
FACR_tran_3rde2v50F16 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
FACR_tran_6the2v50F14 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
FACR_tran_2nde2v50F11 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
FACR_tran_6th_1e2v50F10 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
BACR_tran_4the2v50B15 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
BACR_tran_1ste2v50B13 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
BACR_tran_5the2v50B9 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
BACR_tran_3rde2v50B16 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
BACR_tran_6the2v50B14 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
BACR_tran_2nde2v50B11 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
BACR_tran_6th_1e2v50B10 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
A3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
A3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
A3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
A3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
C1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
C3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
C3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
C3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
C3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
D1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
D3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
D3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
D3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
D3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
E1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
E3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
E3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
E3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
E3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
F1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
F3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
F3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
F3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
F3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
B1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
B3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
B3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
B3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
B3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B, C, D, E
ARO:3000378MexBMexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C, D, E
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpmacrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, cephamycin, penam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic, penemantibiotic effluxCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00873AcrB/AcrD/AcrF family (ACR_tran)AcrB/AcrD/AcrF family- Family

InterPro: Protein Family Classification InterPro Database Homepage

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
A, B, C, D, E
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

ChainsExternal LinkComment
A, B, C, D, E
MemProtMDAnnotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage