2VAX

Crystal structure of deacetylcephalosporin C acetyltransferase (Cephalosporin C-soak)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2vaxa_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
B	d2vaxb_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
C	d2vaxc_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
D	d2vaxd_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
E	d2vaxe_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
F	d2vaxf_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
G	d2vaxg_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
H	d2vaxh_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
I	d2vaxi_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
J	d2vaxj_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
K	d2vaxk_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)
L	d2vaxl_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	O-acetyltransferase	Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG	(Hapsidospora chrysogena ) [TaxId: 5044 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	alpha/beta-Hydrolases	8003806	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_4_2	e2vaxA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
B	Hydrolase_4_2	e2vaxB1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
C	Hydrolase_4_2	e2vaxC1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
D	Hydrolase_4_2	e2vaxD1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
E	Hydrolase_4_2	e2vaxE1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
F	Hydrolase_4_2	e2vaxF1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
G	Hydrolase_4_2	e2vaxG1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
H	Hydrolase_4_2	e2vaxH1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
I	Hydrolase_4_2	e2vaxI1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
J	Hydrolase_4_2	e2vaxJ1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
K	Hydrolase_4_2	e2vaxK1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)
L	Hydrolase_4_2	e2vaxL1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
E	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
F	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
G	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
H	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
I	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
J	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
K	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
L	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00561	alpha/beta hydrolase fold (Abhydrolase_1)	alpha/beta hydrolase fold	This catalytic domain is found in a very wide range of enzymes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	ACETYL-COA--DEACETYLCEPHALOSPORIN C ACETYLTRANSFERASE	acetyltransferase activity O-acyltransferase activity acyltransferase activity O-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity homoserine O-acetyltransferase activity deacetylcephalosporin-C acetyltransferase activity C-acyltransferase activity	serine family amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process homoserine metabolic process metabolic process cellular process small molecule metabolic process sulfur amino acid metabolic process serine family amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process homoserine metabolic process metabolic process cellular process small molecule metabolic process sulfur amino acid metabolic process aspartate family amino acid biosynthetic process aspartate family amino acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process sulfur compound metabolic process methionine biosynthetic process small molecule biosynthetic process L-amino acid biosynthetic process methionine metabolic process amino acid biosynthetic process sulfur compound biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process sulfur amino acid biosynthetic process alpha-amino acid biosynthetic process antibiotic metabolic process antibiotic biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR008220	Homoserine/serine acetyltransferase MetX-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR000073	Alpha/beta hydrolase fold-1	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	OAS	Parent Component: SER RESID: AA0364 PSI-MOD : O-acetyl-L-serine MOD:00369 , N,O-diacetylated L-serine MOD:00648

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.