2VCV

Glutathione transferase A3-3 in complex with glutathione and delta-4- androstene-3-17-dione


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2vcva2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad2vcva1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2vcvb2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2vcvb1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2vcvc2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd2vcvc1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2vcvd2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd2vcvd1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed2vcve2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed2vcve1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Gd2vcvg2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Gd2vcvg1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Hd2vcvh2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Hd2vcvh1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Id2vcvi2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Id2vcvi1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Jd2vcvj2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Jd2vcvj1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Kd2vcvk2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Kd2vcvk1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Nd2vcvn2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Nd2vcvn1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Pd2vcvp2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Pd2vcvp1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd2vcvf2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd2vcvf1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ld2vcvl2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ld2vcvl1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Md2vcvm2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Md2vcvm1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Od2vcvo2 All alpha proteins GST C-terminal domain-like GST C-terminal domain-like Glutathione S-transferase (GST), C-terminal domain automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Od2vcvo1 Alpha and beta proteins (a/b) Thioredoxin fold Thioredoxin-like automated matches automated matches HUMAN (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGST_C_3e2vcvA1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
AGST_N_5e2vcvA2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
BGST_C_3e2vcvB1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
BGST_N_5e2vcvB2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
CGST_C_3e2vcvC1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
CGST_N_5e2vcvC2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
DGST_C_3e2vcvD1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
DGST_N_5e2vcvD2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
EGST_C_3e2vcvE1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
EGST_N_5e2vcvE2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
GGST_C_3e2vcvG1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
GGST_N_5e2vcvG2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
HGST_C_3e2vcvH1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
HGST_N_5e2vcvH2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
IGST_C_3e2vcvI1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
IGST_N_5e2vcvI2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
JGST_C_3e2vcvJ1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
JGST_N_5e2vcvJ2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
KGST_C_3e2vcvK1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
KGST_N_5e2vcvK2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
NGST_C_3e2vcvN1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
NGST_N_5e2vcvN2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
PGST_C_3e2vcvP1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
PGST_N_5e2vcvP2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
FGST_C_3e2vcvF1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
FGST_N_5e2vcvF2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
LGST_C_3e2vcvL1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
LGST_N_5e2vcvL2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
MGST_C_3e2vcvM1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
MGST_N_5e2vcvM2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)
OGST_C_3e2vcvO1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Glutathione S-transferase (GST)-C (From Topology)T: Glutathione S-transferase (GST)-CF: GST_C_3ECOD (1.6)
OGST_N_5e2vcvO2 A: a+b three layersX: Thioredoxin-likeH: Thioredoxin-like (From Topology)T: Thioredoxin-likeF: GST_N_5ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
A1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
B3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
B1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
C3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
C1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
D3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
D1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
E3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
E1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
G3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
G1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
H3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
H1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
I3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
I1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
J3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
J1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
K3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
K1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
N3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
N1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
P3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
P1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
F3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
F1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
L3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
L1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
M3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
M1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)
O3.40.30.10 Alpha Beta 3-Layer(aba) Sandwich Glutaredoxin GlutaredoxinCATH (4.3.0)
O1.20.1050.10 Mainly Alpha Up-down Bundle Glutathione S-transferase Yfyf (Class Pi) Chain A, domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00043Glutathione S-transferase, C-terminal domain (GST_C)Glutathione S-transferase, C-terminal domainGST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins ...GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain [1]. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes [2].
Domain
A, B, C, D, E
PF02798Glutathione S-transferase, N-terminal domain (GST_N)Glutathione S-transferase, N-terminal domainFunction: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity a ...Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity and similarity not previously recognised); HSP26 family of stress-related proteins including auxin-regulated proteins in plants and stringent starvation proteins in E. coli (not known to have GST activity and similarity not previously recognised). The glutathione molecule binds in a cleft between the N- and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain [1].
Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR004046Glutathione S-transferase, C-terminalDomain
A, B, C, D, E
IPR010987Glutathione S-transferase, C-terminal-likeDomain
A, B, C, D, E
IPR003080Glutathione S-transferase, alpha classFamily
A, B, C, D, E
IPR004045Glutathione S-transferase, N-terminalDomain
A, B, C, D, E
IPR050213Glutathione S-transferase superfamilyFamily
A, B, C, D, E
IPR036282Glutathione S-transferase, C-terminal domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR036249Thioredoxin-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR040079Glutathione transferase familyFamily