2VVQ

Crystal structure of Mycobacterium tuberculosis ribose-5-phosphate isomerase B in complex with the inhibitor 5-deoxy-5-phospho-D- ribonate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2vvqb_	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
C	d2vvqc_	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
A	d2vvqa_	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
D	d2vvqd_	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
E	d2vvqe_	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8037818	3000383	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8037818	3000383	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8037818	3000383	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8037818	3000383	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8037818	3000383	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	LacAB_rpiB	e2vvqB1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB	ECOD (1.6)
C	LacAB_rpiB	e2vvqC1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB	ECOD (1.6)
A	LacAB_rpiB	e2vvqA1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB	ECOD (1.6)
D	LacAB_rpiB	e2vvqD1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB	ECOD (1.6)
E	LacAB_rpiB	e2vvqE1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)
C	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)
A	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)
D	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)
E	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02502	Ribose/Galactose Isomerase (LacAB_rpiB)	Ribose/Galactose Isomerase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	RIBOSE-5-PHOSPHATE ISOMERASE B	isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity ribose-5-phosphate isomerase activity catalytic activity	monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process hexose metabolic process primary metabolic process D-allose metabolic process small molecule metabolic process metabolic process cellular process D-allose catabolic process monosaccharide catabolic process small molecule catabolic process monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process hexose metabolic process primary metabolic process D-allose metabolic process small molecule metabolic process metabolic process cellular process D-allose catabolic process monosaccharide catabolic process small molecule catabolic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process generation of precursor metabolites and energy nucleotide metabolic process aldehyde metabolic process purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process pentose-phosphate shunt, non-oxidative branch	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR036569	Sugar-phosphate isomerase, RpiB/LacA/LacB superfamily	Homologous Superfamily
A, B, C, D, E	IPR003500	Sugar-phosphate isomerase, RpiB/LacA/LacB family	Family
A, B, C, D, E	IPR011860	Ribose 5-phosphate isomerase B, Actinobacteria-type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.