2WW1

Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482 in complex with Thiomannobioside

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_hydro_92_N	e2ww1A4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_92_N	ECOD (1.6)
A	Glyco_hydro_92_C	e2ww1A3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_92_C	ECOD (1.6)
A	Glyco_hydro_92_cat	e2ww1A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_92_cat	ECOD (1.6)
B	Glyco_hydro_92_N	e2ww1B4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_92_N	ECOD (1.6)
B	Glyco_hydro_92_C	e2ww1B3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_92_C	ECOD (1.6)
B	Glyco_hydro_92_cat	e2ww1B2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_92_cat	ECOD (1.6)
D	Glyco_hydro_92_N	e2ww1D4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_92_N	ECOD (1.6)
D	Glyco_hydro_92_C	e2ww1D3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_92_C	ECOD (1.6)
D	Glyco_hydro_92_cat	e2ww1D2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_92_cat	ECOD (1.6)
C	Glyco_hydro_92_N	e2ww1C4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_92_N	ECOD (1.6)
C	Glyco_hydro_92_C	e2ww1C3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_92_C	ECOD (1.6)
C	Glyco_hydro_92_cat	e2ww1C2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_92_cat	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.98.10	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
A	3.30.2080.10	Alpha Beta	2-Layer Sandwich	GH92 mannosidase fold	GH92 mannosidase domain	CATH (4.3.0)
A	1.20.1050.60	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
A	1.20.1610.10	Mainly Alpha	Up-down Bundle	Glycosyl hydrolase family fold	alpha-1,2-mannosidases domains	CATH (4.3.0)
B	2.70.98.10	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
B	3.30.2080.10	Alpha Beta	2-Layer Sandwich	GH92 mannosidase fold	GH92 mannosidase domain	CATH (4.3.0)
B	1.20.1050.60	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
B	1.20.1610.10	Mainly Alpha	Up-down Bundle	Glycosyl hydrolase family fold	alpha-1,2-mannosidases domains	CATH (4.3.0)
D	2.70.98.10	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
D	3.30.2080.10	Alpha Beta	2-Layer Sandwich	GH92 mannosidase fold	GH92 mannosidase domain	CATH (4.3.0)
D	1.20.1050.60	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
D	1.20.1610.10	Mainly Alpha	Up-down Bundle	Glycosyl hydrolase family fold	alpha-1,2-mannosidases domains	CATH (4.3.0)
C	2.70.98.10	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
C	3.30.2080.10	Alpha Beta	2-Layer Sandwich	GH92 mannosidase fold	GH92 mannosidase domain	CATH (4.3.0)
C	1.20.1050.60	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
C	1.20.1610.10	Mainly Alpha	Up-down Bundle	Glycosyl hydrolase family fold	alpha-1,2-mannosidases domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07971	Glycosyl hydrolase family 92 catalytic domain (Glyco_hydro_92)	Glycosyl hydrolase family 92 catalytic domain	-	Repeat
A, B, C, D	PF17678	Glycosyl hydrolase family 92 N-terminal domain (Glyco_hydro_92N)	Glycosyl hydrolase family 92 N-terminal domain	This domain is found at the N-terminus of family 92 glycosyl hydrolase proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PUTATIVE ALPHA-1,2-MANNOSIDASE	binding carbohydrate binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cation binding ion binding metal ion binding small molecule binding	carbohydrate derivative catabolic process glycoprotein catabolic process catabolic process carbohydrate derivative metabolic process primary metabolic process protein catabolic process glycoprotein metabolic process macromolecule catabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process carbohydrate metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005887	Glycosyl hydrolase family 92, alpha-1,2-mannosidase, putative	Family
A, B, C, D	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily
A, B, C, D	IPR014718	Glycoside hydrolase-type carbohydrate-binding	Homologous Superfamily
A, B, C, D	IPR012939	Glycosyl hydrolase family 92	Domain
A, B, C, D	IPR050883	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	Family
A, B, C, D	IPR041371	Glycosyl hydrolase family 92 N-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.