2X69

X-ray Structure of Macrophage Inflammatory Protein-1 alpha polymer

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Interleukin 8-like chemokines	8034283	3001955	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Interleukin 8-like chemokines	8034283	3001955	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Interleukin 8-like chemokines	8034283	3001955	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Interleukin 8-like chemokines	8034283	3001955	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Interleukin 8-like chemokines	8034283	3001955	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IL8	e2x69A1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
B	IL8	e2x69B1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
C	IL8	e2x69C1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
E	IL8	e2x69E1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)
D	IL8	e2x69D1	A: beta barrels	X: IL8-related (From Homology)	H: IL8-related	T: IL8	F: IL8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
B	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
C	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
E	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
D	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00048	Small cytokines (intecrine/chemokine), interleukin-8 like (IL8)	Small cytokines (intecrine/chemokine), interleukin-8 like	Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	C-C MOTIF CHEMOKINE 3	CCR5 chemokine receptor binding CCR chemokine receptor binding protein binding binding signaling receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups catalytic activity, acting on a protein protein kinase activity CCR5 chemokine receptor binding CCR chemokine receptor binding protein binding binding signaling receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups catalytic activity, acting on a protein protein kinase activity phosphotransferase activity, alcohol group as acceptor identical protein binding molecular function activator activity signaling receptor activator activity chemokine activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity CCR1 chemokine receptor binding chemoattractant activity enzyme regulator activity enzyme activator activity phospholipase activator activity lipase activator activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication cellular process positive regulation of signaling developmental process multicellular organismal process cellular developmental process glial cell migration nervous system development neurogenesis multicellular organism development gliogenesis cell differentiation anatomical structure development astrocyte cell migration cell migration cell motility system development cell activation regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response positive regulation of locomotion regulation of cell motility regulation of microglial cell migration macrophage migration regulation of glial cell migration positive regulation of cell migration regulation of macrophage migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration positive regulation of microglial cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process locomotion positive regulation of macrophage migration regulation of leukocyte migration microglial cell migration positive regulation of leukocyte migration leukocyte migration positive regulation of glial cell migration immune system process regulation of locomotion mononuclear cell migration positive regulation of chemotaxis regulation of lymphocyte chemotaxis natural killer cell chemotaxis taxis positive regulation of natural killer cell chemotaxis chemotaxis regulation of leukocyte chemotaxis positive regulation of lymphocyte migration lymphocyte migration positive regulation of leukocyte chemotaxis response to chemical regulation of natural killer cell chemotaxis lymphocyte chemotaxis regulation of lymphocyte migration positive regulation of lymphocyte chemotaxis cell chemotaxis regulation of chemotaxis cellular response to chemical stimulus leukocyte chemotaxis cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process neutrophil chemotaxis neutrophil migration granulocyte migration granulocyte chemotaxis response to sterol response to lipid response to alcohol response to oxygen-containing compound response to cholesterol response to organic cyclic compound neuron apoptotic process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process positive regulation of neuron apoptotic process programmed cell death regulation of neuron apoptotic process cell-cell signaling inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of developmental process negative regulation of biological process cell development regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation osteoclast differentiation negative regulation of cellular process regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of hemopoiesis regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process regulation of hemopoiesis negative regulation of multicellular organismal process leukocyte differentiation response to toxic substance regulation of behavior behavior interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production regulation of cytokine production cytokine production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production positive regulation of multicellular organismal process positive regulation of cytokine production MAPK cascade cellular component organization organelle organization cellular component organization or biogenesis cytoskeleton organization regulation of macrophage activation positive regulation of macrophage activation regulation of leukocyte activation positive regulation of microglial cell activation regulation of cell activation positive regulation of neuroinflammatory response myeloid leukocyte activation leukocyte activation macrophage activation positive regulation of cell activation leukocyte activation involved in inflammatory response regulation of neuroinflammatory response positive regulation of leukocyte activation microglial cell activation glial cell activation regulation of microglial cell activation neuroinflammatory response regulated exocytosis cellular localization transport eosinophil activation cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity vesicle-mediated transport localization secretion by cell establishment of localization in cell leukocyte activation involved in immune response eosinophil degranulation leukocyte mediated immunity eosinophil activation involved in immune response secretion immune response export from cell establishment of localization myeloid cell activation involved in immune response immune effector process exocytosis eosinophil mediated immunity granulocyte activation regulation of calcium ion import regulation of calcium ion transport regulation of localization positive regulation of calcium ion transport positive regulation of calcium ion import regulation of transport regulation of monoatomic ion transport calcium ion transport metal ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport eosinophil chemotaxis eosinophil migration response to peptide cellular response to interleukin-1 response to cytokine cellular response to cytokine stimulus response to interleukin-1 ossification osteoblast differentiation viral gene expression biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription biological process involved in symbiotic interaction positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade system process nervous system process regulation of system process sensory perception of pain regulation of nervous system process sensory perception regulation of sensory perception regulation of sensory perception of pain cell surface receptor signaling pathway response to chemokine cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis regulation of biological quality regulation of anatomical structure morphogenesis cellular response to tumor necrosis factor response to tumor necrosis factor response to other organism response to type II interferon defense response to symbiont cellular response to type II interferon response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus monocyte chemotaxis humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide macrophage chemotaxis negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production monoatomic ion transmembrane transport sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum negative regulation of sequestering of calcium ion maintenance of location in cell monoatomic cation transmembrane transport regulation of sequestering of calcium ion release of sequestered calcium ion into cytosol by endoplasmic reticulum calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol calcium ion transmembrane transport T cell chemotaxis T cell migration negative regulation of biomineral tissue development regulation of biomineral tissue development regulation of bone mineralization negative regulation of bone mineralization biomineral tissue development bone mineralization animal organ development tissue development negative regulation of ossification regulation of ossification	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR001811	Chemokine interleukin-8-like domain	Domain
A, B, C, D, E	IPR000827	CC chemokine, conserved site	Conserved Site
A, B, C, D, E	IPR036048	Chemokine interleukin-8-like superfamily	Homologous Superfamily
A, B, C, D, E	IPR039809	Chemokine beta/gamma/delta	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: P10147	status epilepticus HIV infectious disease glomerulonephritis Inflammation malignant mesothelioma pulmonary fibrosis allergic disease brain ischemia atherosclerosis adult acute respiratory distress syndrome arthritic joint disease autoimmune disease cancer hepatocellular carcinoma influenza status epilepticus HIV infectious disease glomerulonephritis Inflammation malignant mesothelioma pulmonary fibrosis allergic disease brain ischemia atherosclerosis adult acute respiratory distress syndrome arthritic joint disease autoimmune disease cancer hepatocellular carcinoma influenza lung carcinoma myocardial ischemia pneumonia coronary artery disease idiopathic interstitial pneumonia ischemia reperfusion injury arteriosclerosis disorder psoriasis susceptibility to HIV infection COVID-19

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.