2Z77

X-ray crystal structure of RV0760c from Mycobacterium tuberculosis in complex with estradiol-17beta-hemisuccinate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2z77b_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Hypothetical protein Rv0760c	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
A	d2z77a_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Hypothetical protein Rv0760c	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
C	d2z77c_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Hypothetical protein Rv0760c	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
D	d2z77d_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ketosteroid isomerase-like	Hypothetical protein Rv0760c	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	NTF2-like	8036529	3000472	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	NTF2-like	8036529	3000472	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NTF2-like	8036529	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8036529	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	SnoaL_1	e2z77B1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
A	SnoaL_1	e2z77A1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
C	SnoaL_1	e2z77C1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)
D	SnoaL_1	e2z77D1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: SnoaL_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02136	Nuclear transport factor 2 (NTF2) domain (NTF2)	Nuclear transport factor 2 (NTF2) domain	This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Putative steroid isomerase	isomerase activity catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity sterol binding organic cyclic compound binding steroid binding lipid binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR002075	Nuclear transport factor 2 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.