2Z81

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LRR_8_3	e2z81A2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_3	ECOD (1.6)
A	LRR_8_1	e2z81A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A	PF13516	Leucine Rich repeat (LRR_6)	Leucine Rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Toll-like receptor 2, Variable lymphocyte receptor B	amide binding amyloid-beta binding binding peptide binding diacyl lipopeptide binding lipid binding lipopeptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein-containing complex binding molecular transducer activity amide binding amyloid-beta binding binding peptide binding diacyl lipopeptide binding lipid binding lipopeptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein-containing complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity triacyl lipopeptide binding pattern recognition receptor activity carbohydrate derivative binding lipoteichoic acid binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process behavior multicellular organismal process system process learning learning or memory nervous system process cognition cellular response to stimulus regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus toll-like receptor signaling pathway signaling response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway MyD88-dependent toll-like receptor signaling pathway positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response regulation of inflammatory response positive regulation of inflammatory response inflammatory response catabolic process macroautophagy cellular metabolic process autophagy xenophagy cellular catabolic process process utilizing autophagic mechanism interleukin-1 production cellular biosynthetic process positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of interleukin-1 beta production regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of interleukin-1 production regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production positive regulation of cellular biosynthetic process positive regulation of xenophagy regulation of autophagy positive regulation of macroautophagy positive regulation of autophagy regulation of xenophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of chemokine production chemokine production positive regulation of chemokine production positive regulation of cell communication regulation of signaling positive regulation of signal transduction positive regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction regulation of cell communication positive regulation of signaling cellular response to lipoteichoic acid response to oxygen-containing compound response to lipoteichoic acid cellular response to molecule of bacterial origin cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus response to bacterium response to chemical response to molecule of bacterial origin interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production regulation of immune effector process regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process interleukin-17 production negative regulation of interleukin-17 production negative regulation of metabolic process negative regulation of cytokine production negative regulation of cellular biosynthetic process negative regulation of gene expression regulation of interleukin-17 production negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process organic acid metabolic process cell activation myeloid leukocyte activation leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation glial cell activation neuroinflammatory response cellular response to bacterial lipoprotein response to bacterial lipoprotein response to bacterial lipopeptide cellular response to bacterial lipopeptide cellular response to triacyl bacterial lipopeptide response to triacyl bacterial lipopeptide response to molecule of fungal origin response to fungus cellular developmental process cellular component assembly involved in morphogenesis cell development glial cell development myelin assembly cellular component organization cellular component biogenesis multicellular organism development neurogenesis cellular anatomical entity morphogenesis cellular component assembly gliogenesis axon ensheathment ensheathment of neurons cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process oligodendrocyte development central nervous system myelination nervous system development central nervous system myelin formation myelination anatomical structure morphogenesis axon ensheathment in central nervous system central nervous system development oligodendrocyte differentiation glial cell differentiation anatomical structure formation involved in morphogenesis immune response-regulating cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway cell surface receptor signaling pathway myeloid leukocyte differentiation mononuclear cell differentiation microglia differentiation hemopoiesis macrophage differentiation microglia development myeloid cell differentiation myeloid cell development leukocyte differentiation cellular response to nitrogen compound cellular response to peptidoglycan response to nitrogen compound response to peptidoglycan positive regulation of ERK1 and ERK2 cascade intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration cell migration cell motility locomotion regulation of leukocyte migration positive regulation of neutrophil migration positive regulation of leukocyte migration neutrophil migration granulocyte migration leukocyte migration regulation of locomotion regulation of neutrophil migration response to diacyl bacterial lipopeptide cellular response to diacyl bacterial lipopeptide interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production regulation of cellular component organization regulation of developmental process regulation of nervous system development negative regulation of cell junction assembly cell junction assembly negative regulation of nervous system development regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly regulation of multicellular organismal development negative regulation of cellular component organization negative regulation of developmental process negative regulation of synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly negative regulation of synapse assembly detection of bacterial lipoprotein detection of external biotic stimulus detection of molecule of bacterial origin detection of biotic stimulus detection of bacterium detection of diacyl bacterial lipopeptide detection of stimulus detection of chemical stimulus detection of other organism detection of bacterial lipopeptide regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production detection of triacyl bacterial lipopeptide regulation of interferon-beta production interferon-beta production positive regulation of type I interferon production type I interferon production positive regulation of interferon-beta production regulation of type I interferon production regulation of cytoskeleton organization regulation of actin filament-based process regulation of cellular component size regulation of protein-containing complex assembly protein-containing complex assembly actin filament-based process negative regulation of protein polymerization regulation of actin filament polymerization negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization actin cytoskeleton organization protein-containing complex organization negative regulation of cytoskeleton organization actin filament organization regulation of actin polymerization or depolymerization regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization regulation of anatomical structure size regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process dendritic cell cytokine production regulation of dendritic cell cytokine production leukocyte mediated immunity regulation of leukocyte mediated immunity negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of localization import into cell transport negative regulation of transport negative regulation of endocytosis vesicle-mediated transport localization negative regulation of phagocytosis phagocytosis regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization endocytosis negative regulation of interleukin-12 production response to lipid response to fatty acid positive regulation of nervous system development regulation of cell differentiation regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis regulation of cell development positive regulation of developmental process positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation regulation of glial cell differentiation positive regulation of cell development positive regulation of glial cell differentiation regulation of oligodendrocyte differentiation positive regulation of interleukin-18 production regulation of interleukin-18 production interleukin-18 production regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production defense response to Gram-positive bacterium defense response to bacterium	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle Golgi apparatus endomembrane system protein-containing complex plasma membrane protein complex Toll-like receptor 2-Toll-like receptor 6 protein complex plasma membrane signaling receptor complex membrane protein complex receptor complex cell body Toll-like receptor 1-Toll-like receptor 2 protein complex membrane microdomain membrane raft cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR017241	Toll-like receptor	Family
A	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.