Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2blea_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel Inosine monophosphate dehydrogenase (IMPDH) automated matches automated matches (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyInosine monophosphate dehydrogenase (IMPDH) 8081559 3000263 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AIMPDH_1ste2bleA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: IMPDH_1stECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00478IMP dehydrogenase / GMP reductase domain (IMPDH)IMP dehydrogenase / GMP reductase domainThis family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a membe ...This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a member of the common phosphate binding site TIM barrel family.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
GMP REDUCTASE I

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
GMP reductase  M-CSA #982

Guanosine monophosphate reductase (GMPR) is crucial for catalysis of the irreversible GMP deamination to IMP with the use of NADPH. It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and thus maintains the intracellular balance of A and G nucleotides. GMP is a homotetramer with mixed alpha helices and beta sheets.The monomers are stabilised by interactions across their edges and through Cys-Cys bonds. GMPR1 inhibitors are tested for applications is treating Alzheimer's disease and the increase of GMPR expression is linked to suppression of melanoma cancers.

Defined by 3 residues: CYS:A-208 [auth A-186]THR:A-210 [auth A-188]GLU:A-311 [auth A-289]
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