Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyFMN-linked oxidoreductases 8058084 3000014 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFMN-linked oxidoreductases 8058084 3000014 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADHO_dhe2dorA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: DHO_dhECOD (1.6)
BDHO_dhe2dorB1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: DHO_dhECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
A2.30.26.10 Mainly Beta Roll Dihydroorotate Dehydrogenase A chain A, domain 2CATH (4.3.0)
B3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
B2.30.26.10 Mainly Beta Roll Dihydroorotate Dehydrogenase A chain A, domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01180Dihydroorotate dehydrogenase (DHO_dh)Dihydroorotate dehydrogenase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
DIHYDROOROTATE DEHYDROGENASE A

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
dihydroorotate dehydrogenase (fumarate)  M-CSA #892

Dihydroorotate dehydrogenase (DHOD) catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires FMN as co-factor. This enzyme represents family 1 (specifically 1A) which are mostly found in bacteria and utilise fumarate as the acceptor

Defined by 2 residues: LYS:A-43CYS:A-130
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