Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyRas-like P-loop GTPases 8057484 3002022 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyRas-like P-loop GTPases 8057484 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AKOG2319_like_1ste2efeA2 A: alpha bundlesX: Bromodomain-likeH: RABEX-5 helical domain (From Topology)T: RABEX-5 helical domainF: KOG2319_like_1stECOD (1.6)
AVPS9e2efeA1 A: alpha complex topologyX: VPS9 domain (From Topology)H: VPS9 domain (From Topology)T: VPS9 domainF: VPS9ECOD (1.6)
CKOG2319_like_1ste2efeC2 A: alpha bundlesX: Bromodomain-likeH: RABEX-5 helical domain (From Topology)T: RABEX-5 helical domainF: KOG2319_like_1stECOD (1.6)
CVPS9e2efeC1 A: alpha complex topologyX: VPS9 domain (From Topology)H: VPS9 domain (From Topology)T: VPS9 domainF: VPS9ECOD (1.6)
BRase2efeB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
DRase2efeD1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF18151Domain of unknown function (DUF5601) (DUF5601)Domain of unknown function (DUF5601)This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature ...This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature [1].
Domain
A, C
PF02204Vacuolar sorting protein 9 (VPS9) domain (VPS9)Vacuolar sorting protein 9 (VPS9) domain- Family
B, D
PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Similarity to vacuolar protein sorting-associated protein VPS9 -
B, D
Small GTP-binding protein-like