Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad2gmha1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD-linked reductases, N-terminal domain Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO (Sus scrofa ) [TaxId: 9823 ], SCOPe (2.08)
Ad2gmha2 Alpha and beta proteins (a+b) FAD-linked reductases, C-terminal domain FAD-linked reductases, C-terminal domain Electron transfer flavoprotein-ubiquinone oxidoreductase-like Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO (Sus scrofa ) [TaxId: 9823 ], SCOPe (2.08)
Ad2gmha3 Alpha and beta proteins (a+b) Ferredoxin-like 4Fe-4S ferredoxins ETF-QO domain-like Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO (Sus scrofa ) [TaxId: 9823 ], SCOPe (2.08)
Bd2gmhb1 Alpha and beta proteins (a/b) FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain FAD-linked reductases, N-terminal domain Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO (Sus scrofa ) [TaxId: 9823 ], SCOPe (2.08)
Bd2gmhb2 Alpha and beta proteins (a+b) FAD-linked reductases, C-terminal domain FAD-linked reductases, C-terminal domain Electron transfer flavoprotein-ubiquinone oxidoreductase-like Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO (Sus scrofa ) [TaxId: 9823 ], SCOPe (2.08)
Bd2gmhb3 Alpha and beta proteins (a+b) Ferredoxin-like 4Fe-4S ferredoxins ETF-QO domain-like Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO (Sus scrofa ) [TaxId: 9823 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyETF-ubiquinone oxidoreductase-like 8001414 4000127 SCOP2 (2022-06-29)
ASCOP2 FamilyETF-QO domain-like 8001420 4000064 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyFlavoreductase-like 8001416 3000055 SCOP2 (2022-06-29)
ASCOP2 Superfamily4Fe-4S ferredoxins 8001550 3000020 SCOP2 (2022-06-29)
BSCOP2B Superfamily4Fe-4S ferredoxins 8001550 3000020 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFlavoreductase-like 8001416 3000055 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AETF_QOe2gmhA1 A: a+b two layersX: 4Fe-4S ferredoxin (From Topology)H: 4Fe-4S ferredoxin (From Topology)T: 4Fe-4S ferredoxinF: ETF_QOECOD (1.6)
AKOG2415e2gmhA2 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD-linked reductases-C (From Topology)T: FAD-linked reductases-CF: KOG2415ECOD (1.6)
AFAD_binding_3_1ste2gmhA3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: FAD_binding_3_1stECOD (1.6)
BETF_QOe2gmhB1 A: a+b two layersX: 4Fe-4S ferredoxin (From Topology)H: 4Fe-4S ferredoxin (From Topology)T: 4Fe-4S ferredoxinF: ETF_QOECOD (1.6)
BKOG2415e2gmhB2 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: FAD-linked reductases-C (From Topology)T: FAD-linked reductases-CF: KOG2415ECOD (1.6)
BFAD_binding_3_1ste2gmhB3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: FAD_binding_3_1stECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF21162ETF-QO, ubiquinone-binding (ETFQO_UQ-bd)ETF-QO, ubiquinone-bindingElectron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) is a a 4Fe4S flavoprotein located in the inner mitochondrial membrane and catalyses ubiquinone (UQ) reduction. It forms a single structural domain with three functional regions (that b ...Electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) is a a 4Fe4S flavoprotein located in the inner mitochondrial membrane and catalyses ubiquinone (UQ) reduction. It forms a single structural domain with three functional regions (that bind FAD, the 4Fe4S cluster, and UQ) which are closely packed and share structural elements [1]. This domain includes the residues involved in UQ binding [1]. This domain is also found in FixC proteins from bacteria, which share similarities with ETF-QO [2].
Domain
A, B
PF13450NAD(P)-binding Rossmann-like domain (NAD_binding_8)NAD(P)-binding Rossmann-like domain- Domain
A, B
PF05187Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S (ETF_QO)Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Electron transfer flavoprotein-ubiquinone oxidoreductase

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
electron-transferring-flavoprotein dehydrogenase  M-CSA #281

Electron transfer flavoprotein-ubiquinone oxidoreductase is oxidised by the diffusible ubiquinone. The ubiquinol product relays electrons onto complex III. The enzyme links electrons from the oxidations of fatty acids to the mitochondrial respiratory chain.

Defined by 7 residues: SER:A-82ARG:A-331THR:A-367CYS:A-528CYS:A-553CYS:A-556CYS:A-559
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