2I0U
Crystal structures of phospholipases A2 from Vipera nikolskii venom revealing Triton X-100 bound in hydrophobic channel
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth E] | d2i0ue_ | All alpha proteins | Phospholipase A2, PLA2 | Phospholipase A2, PLA2 | Vertebrate phospholipase A2 | automated matches | (Vipera nikolskii ) [TaxId: 1808362 ], | SCOPe (2.08) |
B [auth A] | d2i0ua_ | All alpha proteins | Phospholipase A2, PLA2 | Phospholipase A2, PLA2 | Vertebrate phospholipase A2 | automated matches | (Vipera nikolskii ) [TaxId: 1808362 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth E] | SCOP2B Superfamily | Phospholipase A2, PLA2 | 8062725 | 3001690 | SCOP2B (2022-06-29) |
B [auth A] | SCOP2 Family | Vertebrate phospholipase A2 | 8062724 | 4001493 | SCOP2 (2022-06-29) |
B [auth A] | SCOP2 Superfamily | Phospholipase A2, PLA2 | 8062725 | 3001690 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth E] | Phospholip_A2_1 | e2i0uE1 | A: few secondary structure elements | X: Phospholipase A2, PLA2 (From Topology) | H: Phospholipase A2, PLA2 (From Topology) | T: Phospholipase A2, PLA2 | F: Phospholip_A2_1 | ECOD (1.6) |
B [auth A] | Phospholip_A2_1 | e2i0uA1 | A: few secondary structure elements | X: Phospholipase A2, PLA2 (From Topology) | H: Phospholipase A2, PLA2 (From Topology) | T: Phospholipase A2, PLA2 | F: Phospholip_A2_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth E] | 1.20.90.10 | Mainly Alpha | Up-down Bundle | Phospholipase A2 | Phospholipase A2 domain | CATH (4.3.0) |
B [auth A] | 1.20.90.10 | Mainly Alpha | Up-down Bundle | Phospholipase A2 | Phospholipase A2 domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth E], B [auth A] | PF00068 | Phospholipase A2 (Phospholip_A2_1) | Phospholipase A2 | Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disul ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth E], B [auth A] | IPR033112 | Phospholipase A2, aspartic acid active site | Active Site |
A [auth E], B [auth A] | IPR033113 | Phospholipase A2, histidine active site | Active Site |
A [auth E], B [auth A] | IPR001211 | Phospholipase A2 | Family |
A [auth E], B [auth A] | IPR036444 | Phospholipase A2 domain superfamily | Homologous Superfamily |
A [auth E], B [auth A] | IPR016090 | Phospholipase A2 domain | Domain |
Membrane Protein Annotation: OPM OPM Database Homepage
Chains | External Link | Type | Class | Superfamily | Family |
---|---|---|---|---|---|
OPM | Monotopic/peripheral | All alpha monotopic/peripheral | Secretory phospholipase A2 | Vertebrate secretory phospholipase A2 |