Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd2pmwb1 Alpha and beta proteins (a/b) Subtilisin-like Subtilisin-like Subtilases automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd2pmwb2 Small proteins Resistin Resistin PCSK9 C-terminal domain-like automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilySubtilisin-like 8069727 3000226 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AInhibitor_I9e2pmwA1 A: a+b two layersX: Alpha-beta plaitsH: Protease propeptides/inhibitors (From Topology)T: Protease propeptides/inhibitorsF: Inhibitor_I9ECOD (1.6)
BPCSK9_C-CRD_2nde2pmwB3 A: beta duplicates or obligate multimersX: Resistin (From Topology)H: Resistin (From Topology)T: ResistinF: PCSK9_C-CRD_2ndECOD (1.6)
BPCSK9_C-CRD_1ste2pmwB2 A: beta duplicates or obligate multimersX: Resistin (From Topology)H: Resistin (From Topology)T: ResistinF: PCSK9_C-CRD_1stECOD (1.6)
BPCSK9_C-CRD_3rde2pmwB4 A: beta duplicates or obligate multimersX: Resistin (From Topology)H: Resistin (From Topology)T: ResistinF: PCSK9_C-CRD_3rdECOD (1.6)
BPeptidase_S8e2pmwB1 A: a/b three-layered sandwichesX: Subtilisin-likeH: Subtilisin-like (From Topology)T: Subtilisin-likeF: Peptidase_S8ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF05922Peptidase inhibitor I9 (Inhibitor_I9)Peptidase inhibitor I9This family includes the proteinase B inhibitor from Saccharomyces cerevisiae and the activation peptides from peptidases of the subtilisin family. The subtilisin propeptides are known to function as molecular chaperones, assisting in the folding of ...This family includes the proteinase B inhibitor from Saccharomyces cerevisiae and the activation peptides from peptidases of the subtilisin family. The subtilisin propeptides are known to function as molecular chaperones, assisting in the folding of the mature peptidase [1], but have also been shown to act as 'temporary inhibitors' [2].
Domain
PF00082Subtilase family (Peptidase_S8)Subtilase familySubtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see Pfam:PF00089). Structure is an alpha/beta fold containing a 7 ...Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see Pfam:PF00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.
Domain
PF18463Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain (PCSK9_C3)Proprotein convertase subtilisin-like/kexin type 9 C-terminal domainThis entry represents a subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) [1]. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R ...This entry represents a subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) [1]. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) [2]. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded beta-subdomains arranged in a pseudothreefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds [1].
Domain
PF18464Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain (PCSK9_C2)Proprotein convertase subtilisin-like/kexin type 9 C-terminal domainThis entry represents a subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) [1]. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R ...This entry represents a subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) [1]. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) [2]. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded beta-subdomains arranged in a pseudothreefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Proprotein convertase subtilisin/kexin type 9
Proprotein convertase subtilisin/kexin type 9

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosQ8NBP7
PharosQ8NBP7