Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilySH3-domain 8065211 3000153 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APH_10e2pz1A2 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PH_10ECOD (1.6)
ASH3_1e2pz1A1 A: beta barrelsX: SH3H: SH3T: SH3F: SH3_1ECOD (1.6)
ARhoGEFe2pz1A3 A: alpha bundlesX: DH domain-likeH: DBL homology domain (DH-domain) (From Topology)T: DBL homology domain (DH-domain)F: RhoGEFECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.30.30.40 Mainly Beta Roll SH3 type barrels. SH3 DomainsCATH (4.3.0)
A1.20.900.10 Mainly Alpha Up-down Bundle Dbl Homology Domain Chain ACATH (4.3.0)
A2.30.29.30 Mainly Beta Roll PH-domain like Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00018SH3 domain (SH3_1)SH3 domainSH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.Domain
PF22697SOS1/NGEF-like PH domain (SOS1_NGEF_PH)SOS1/NGEF-like PH domainThis is a PH domain found in a diverse group of animal proteins such as Ephexin-1, SOS1 from human and related RhoGEFs [1-5].Domain
PF00621RhoGEF domain (RhoGEF)RhoGEF domainGuanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Rho guanine nucleotide exchange factor 4