Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASSL_OBe2rdhA1 A: beta barrelsX: OB-foldH: Bacterial enterotoxins (From Topology)T: Bacterial enterotoxinsF: SSL_OBECOD (1.6)
AStap_Strp_tox_Ce2rdhA2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Stap_Strp_tox_CECOD (1.6)
BSSL_OBe2rdhB1 A: beta barrelsX: OB-foldH: Bacterial enterotoxins (From Topology)T: Bacterial enterotoxinsF: SSL_OBECOD (1.6)
BStap_Strp_tox_Ce2rdhB2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Stap_Strp_tox_CECOD (1.6)
CSSL_OBe2rdhC1 A: beta barrelsX: OB-foldH: Bacterial enterotoxins (From Topology)T: Bacterial enterotoxinsF: SSL_OBECOD (1.6)
CStap_Strp_tox_Ce2rdhC2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Stap_Strp_tox_CECOD (1.6)
DSSL_OBe2rdhD1 A: beta barrelsX: OB-foldH: Bacterial enterotoxins (From Topology)T: Bacterial enterotoxinsF: SSL_OBECOD (1.6)
DStap_Strp_tox_Ce2rdhD2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Stap_Strp_tox_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.20.120 Alpha Beta Roll Ubiquitin-like (UB roll) CATH (4.3.0)
A2.40.50.110 Mainly Beta Beta Barrel OB fold (Dihydrolipoamide Acetyltransferase, E2P) CATH (4.3.0)
B3.10.20.120 Alpha Beta Roll Ubiquitin-like (UB roll) CATH (4.3.0)
B2.40.50.110 Mainly Beta Beta Barrel OB fold (Dihydrolipoamide Acetyltransferase, E2P) CATH (4.3.0)
C3.10.20.120 Alpha Beta Roll Ubiquitin-like (UB roll) CATH (4.3.0)
C2.40.50.110 Mainly Beta Beta Barrel OB fold (Dihydrolipoamide Acetyltransferase, E2P) CATH (4.3.0)
D3.10.20.120 Alpha Beta Roll Ubiquitin-like (UB roll) CATH (4.3.0)
D2.40.50.110 Mainly Beta Beta Barrel OB fold (Dihydrolipoamide Acetyltransferase, E2P) CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF09199Staphylococcal superantigen-like OB-fold domain (SSL_OB)Staphylococcal superantigen-like OB-fold domainThis OB-fold domain folds into a five-stranded beta-barrel [1]. Members of this family are found in various staphylococcal toxins described as staphylococcal superantigen-like (SSL) proteins that are related to the staphylococcal enterotoxins (SEs) o ...This OB-fold domain folds into a five-stranded beta-barrel [1]. Members of this family are found in various staphylococcal toxins described as staphylococcal superantigen-like (SSL) proteins that are related to the staphylococcal enterotoxins (SEs) or superantigens. These SSL proteins of which 11 have so far been characterised have a typical SE tertiary structure consisting of a distinct oligonucleotide/oligosaccharide binding (OB-fold), this domain, linked to a beta-grasp domain, family Stap_Strp_tox_C, Pfam:PF02876. SSLs do not bind to T-cell receptors or major histocompatibility complex class II molecules and do not stimulate T cells. SSLs target components of innate immunity, such as complement, Fc receptors, and myeloid cells 2,3,4,5,6,7,8]. SSL protein 7 (SSL7) is the best characterised of the SSLs and binds complement factor C5 and IgA with high affinity and inhibits the end stage of complement activation and IgA binding to FcalphaR [8].
Domain
A, B, C, D
PF02876Staphylococcal/Streptococcal toxin, beta-grasp domain (Stap_Strp_tox_C)Staphylococcal/Streptococcal toxin, beta-grasp domain- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Superantigen-like protein 11- -