Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilySMAD/FHA domain-like 8058041 3000137 SCOP2B (2022-06-29)
BSCOP2B SuperfamilySMAD/FHA domain-like 8058041 3000137 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFHA_1e2w3oA1 A: beta sandwichesX: SMAD/FHA domain (From Topology)H: SMAD/FHA domain (From Topology)T: SMAD/FHA domainF: FHA_1ECOD (1.6)
BFHA_1e2w3oB1 A: beta sandwichesX: SMAD/FHA domain (From Topology)H: SMAD/FHA domain (From Topology)T: SMAD/FHA domainF: FHA_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.60.200.20 Mainly Beta Sandwich Tumour Suppressor Smad4 CATH (4.3.0)
B2.60.200.20 Mainly Beta Sandwich Tumour Suppressor Smad4 CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF17913FHA domain (FHA_2)FHA domainThis entry represents a divergent FHA domain which in PNK binds to phosphorylated segment of XRCC1 [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
C, D
DNA REPAIR PROTEIN XRCC1
A, B
BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C, D
PharosP18887
A, B
PharosQ96T60

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
C, D
SEP Parent Component: SER

RESIDAA0037

PSI-MOD :  O-phospho-L-serine MOD:00046
C, D
TPO Parent Component: THR

RESIDAA0037 , AA0038

PSI-MOD :  O-phospho-L-serine MOD:00046 , O-phospho-L-threonine MOD:00047