2W3O
Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | FHA_1 | e2w3oA1 | A: beta sandwiches | X: SMAD/FHA domain (From Topology) | H: SMAD/FHA domain (From Topology) | T: SMAD/FHA domain | F: FHA_1 | ECOD (1.6) |
B | FHA_1 | e2w3oB1 | A: beta sandwiches | X: SMAD/FHA domain (From Topology) | H: SMAD/FHA domain (From Topology) | T: SMAD/FHA domain | F: FHA_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.60.200.20 | Mainly Beta | Sandwich | Tumour Suppressor Smad4 | CATH (4.3.0) | |
B | 2.60.200.20 | Mainly Beta | Sandwich | Tumour Suppressor Smad4 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF17913 | FHA domain (FHA_2) | FHA domain | This entry represents a divergent FHA domain which in PNK binds to phosphorylated segment of XRCC1 [1]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR008979 | Galactose-binding-like domain superfamily | Homologous Superfamily | |
IPR045080 | XRCC1, first (central) BRCT domain | Domain | |
IPR001357 | BRCT domain | Domain | |
IPR002706 | DNA-repair protein Xrcc1, N-terminal | Domain | |
IPR036420 | BRCT domain superfamily | Homologous Superfamily | |
IPR006551 | Polynucleotide 3'-phosphatase | Domain | |
IPR041388 | PNK, FHA domain | Domain | |
IPR006550 | Bifunctional polynucleotide phosphatase/kinase PNKP | Family | |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily | |
IPR006549 | HAD-superfamily hydrolase,subfamily IIIA | Domain | |
IPR023214 | HAD superfamily | Homologous Superfamily | |
IPR008984 | SMAD/FHA domain superfamily | Homologous Superfamily | |
IPR013954 | Polynucleotide kinase 3 phosphatase | Family | |
IPR036412 | HAD-like superfamily | Homologous Superfamily |