3AHH

H142A mutant of Phosphoketolase from Bifidobacterium Breve complexed with acetyl thiamine diphosphate

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	TK C-terminal domain-like	8052431	3000424	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thiamin diphosphate-binding fold (THDP-binding)	8052433	3001790	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thiamin diphosphate-binding fold (THDP-binding)	8052432	3001790	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	XFP_C	e3ahhA3	A: a/b three-layered sandwiches	X: TK C-terminal domain-like (From Topology)	H: TK C-terminal domain-like (From Topology)	T: TK C-terminal domain-like	F: XFP_C	ECOD (1.6)
A	XFP	e3ahhA2	A: a/b three-layered sandwiches	X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	T: Thiamin diphosphate-binding fold (THDP-binding)	F: XFP	ECOD (1.6)
A	XFP_N	e3ahhA1	A: a/b three-layered sandwiches	X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	T: Thiamin diphosphate-binding fold (THDP-binding)	F: XFP_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	CATH (4.3.0)
A	3.40.50.920	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09363	XFP C-terminal domain (XFP_C)	XFP C-terminal domain	-	Family
A	PF09364	XFP N-terminal domain (XFP_N)	XFP N-terminal domain	-	Family
A	PF03894	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase (XFP)	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Xylulose 5-phosphate/fructose 6-phosphate phosphoketolase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity	carbohydrate metabolic process primary metabolic process metabolic process cellular process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019789	Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, thiamine diphosphate binding site	Binding Site
A	IPR019790	Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, conserved site	Conserved Site
A	IPR023962	Probable phosphoketolase	Family
A	IPR018969	Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, C-terminal	Domain
A	IPR005593	Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase	Family
A	IPR029061	Thiamin diphosphate-binding fold	Homologous Superfamily
A	IPR009014	Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II	Homologous Superfamily
A	IPR018970	Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.