Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth C]TetR_Ne3angC1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_NECOD (1.6)
A [auth C]EUF08055e3angC2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: EUF08055ECOD (1.6)
B [auth A]TetR_Ne3angA1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_NECOD (1.6)
B [auth A]EUF08055e3angA2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: EUF08055ECOD (1.6)
C [auth D]TetR_Ne3angD1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_NECOD (1.6)
C [auth D]EUF08055e3angD2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: EUF08055ECOD (1.6)
D [auth B]TetR_Ne3angB1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_NECOD (1.6)
D [auth B]EUF08055e3angB2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: EUF08055ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth C]1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)
B [auth A]1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)
C [auth D]1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)
D [auth B]1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth C],
B [auth A],
C [auth D],
D [auth B]
PF00440Bacterial regulatory proteins, tetR family (TetR_N)Bacterial regulatory proteins, tetR family- Domain
A [auth C],
B [auth A],
C [auth D],
D [auth B]
PF21776TetR/AcrR family transcriptional repressors, C-terminal domain (TetR_C_44)TetR/AcrR family transcriptional repressors, C-terminal domainTetR/AcrR family transcriptional repressors regulate a wide range of cellular activities, including multidrug resistance, virulence and pathogenicity of bacteria. Members of this family are two domain proteins consisting of N-terminal HTH DNA-binding ...TetR/AcrR family transcriptional repressors regulate a wide range of cellular activities, including multidrug resistance, virulence and pathogenicity of bacteria. Members of this family are two domain proteins consisting of N-terminal HTH DNA-binding domain and C-terminal ligand recognition domain. This entry represents the C-terminal domain that besides the ligand recognition, is involved in dimerisation. In contrast to the N-terminal domain, this domain is more diverse allowing different regulators in the TetR/AcrR family to accommodate specific sets of inducing ligands.
Domain