Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3apya_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)
Bd3apyb_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)
Cd3apyc_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)
Dd3apyd_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)
Ed3apye_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)
Fd3apyf_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)
Gd3apyg_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)
Hd3apyh_ Alpha and beta proteins (a/b) TIM beta/alpha-barrel FAD-linked oxidoreductase Methylenetetrahydrofolate reductase automated matches (Thermus thermophilus HB8 ) [TaxId: 300852 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyMethylenetetrahydrofolate reductase 8076148 4003348 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyFAD-linked oxidoreductase 8076149 3000663 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMTHFRe3apyA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)
BMTHFRe3apyB1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)
CMTHFRe3apyC1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)
DMTHFRe3apyD1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)
EMTHFRe3apyE1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)
FMTHFRe3apyF1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)
GMTHFRe3apyG1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)
HMTHFRe3apyH1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MTHFRECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)
B3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)
C3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)
D3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)
E3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)
F3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)
G3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)
H3.20.20.220 Alpha Beta Alpha-Beta Barrel TIM Barrel CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02219Methylenetetrahydrofolate reductase (MTHFR)Methylenetetrahydrofolate reductaseThis family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from bacteria and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The structure for this domain is known [1] to be a TIM barrel.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Methylenetetrahydrofolate reductase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR003171Methylenetetrahydrofolate reductase-likeFamily
A, B, C, D, E
IPR029041FAD-linked oxidoreductase-likeHomologous Superfamily
A, B, C, D, E
IPR0046205,10-methylenetetrahydrofolate reductaseFamily