3B7U
Leukotriene A4 Hydrolase Complexed with KELatorphan
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth X] | d3b7ux1 | All alpha proteins | alpha-alpha superhelix | ARM repeat | Leukotriene A4 hydrolase C-terminal domain | Leukotriene A4 hydrolase C-terminal domain | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A [auth X] | d3b7ux2 | All beta proteins | Zn aminopeptidase N-terminal domain | Zn aminopeptidase N-terminal domain | Zn aminopeptidase N-terminal domain | Leukotriene A4 hydrolase N-terminal domain | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A [auth X] | d3b7ux3 | Alpha and beta proteins (a+b) | Zincin-like | Metalloproteases ('zincins'), catalytic domain | Zn aminopeptidase catalytic domain | Leukotriene A4 hydrolase catalytic domain | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth X] | SCOP2B Superfamily | Metalloproteases (zincins), catalytic domain | 8038934 | 3001975 | SCOP2B (2022-06-29) |
A [auth X] | SCOP2B Superfamily | ARM repeat-like | 8038928 | 3000116 | SCOP2B (2022-06-29) |
A [auth X] | SCOP2B Superfamily | Leukotriene A4 hydrolase N-terminal domain | 8038930 | 3000390 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth X] | Peptidase_M1_2 | e3b7uX1 | A: beta sandwiches | X: Baculovirus p35 protein-related (From Topology) | H: Baculovirus p35 protein-related (From Topology) | T: Baculovirus p35 protein-related | F: Peptidase_M1_2 | ECOD (1.6) |
A [auth X] | Leuk-A4-hydro_C | e3b7uX2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: Leuk-A4-hydro_C | ECOD (1.6) |
A [auth X] | Peptidase_M1_1 | e3b7uX3 | A: mixed a+b and a/b | X: Zincin-like | H: Metalloproteases (zincins) catalytic domain (From Topology) | T: Metalloproteases (zincins) catalytic domain | F: Peptidase_M1_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth X] | 2.60.40.1730 | Mainly Beta | Sandwich | Immunoglobulin-like | tricorn interacting facor f3 domain | CATH (4.3.0) |
A [auth X] | 3.30.2010.30 | Alpha Beta | 2-Layer Sandwich | Zincin-like | CATH (4.3.0) | |
A [auth X] | 1.10.390.10 | Mainly Alpha | Orthogonal Bundle | Neutral Protease | domain 2 | CATH (4.3.0) |
A [auth X] | 1.25.40.320 | Mainly Alpha | Alpha Horseshoe | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth X] | PF09127 | Leukotriene A4 hydrolase, C-terminal (Leuk-A4-hydro_C) | Leukotriene A4 hydrolase, C-terminal | - | Repeat |
A [auth X] | PF01433 | Peptidase family M1 domain (Peptidase_M1) | Peptidase family M1 domain | Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activ ... | Domain |
A [auth X] | PF17900 | Peptidase M1 N-terminal domain (Peptidase_M1_N) | Peptidase M1 N-terminal domain | This domain is found at the N-terminus of aminopeptidases from the M1 family. | Domain |