3BF6

Thrombin:suramin complex

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
B [auth H]SCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B [auth H]2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B [auth H]PF00089Trypsin (Trypsin)Trypsin- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B [auth H]Thrombin, HEAVY CHAIN
C [auth I]PHE-PRO-ARG---
A [auth L]Thrombin, LIGHT CHAIN

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
B [auth H]IPR018992Thrombin light chainDomain
B [auth H]IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
B [auth H]IPR003966Prothrombin/thrombinFamily
B [auth H]IPR018114Serine proteases, trypsin family, histidine active siteActive Site
B [auth H]IPR009003Peptidase S1, PA clanHomologous Superfamily
B [auth H]IPR033116Serine proteases, trypsin family, serine active siteActive Site
B [auth H]IPR001254Serine proteases, trypsin domainDomain
B [auth H]IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
B [auth H]IPR000001KringleDomain
B [auth H]IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
B [auth H]IPR051659Serine Protease S1 Domain-Containing ProteinFamily
B [auth H]IPR018056Kringle, conserved siteConserved Site
B [auth H]IPR013806Kringle-like foldHomologous Superfamily
B [auth H]IPR038178Kringle superfamilyHomologous Superfamily
B [auth H]IPR001314Peptidase S1A, chymotrypsin familyFamily
B [auth H]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A [auth L]IPR018992Thrombin light chainDomain
A [auth L]IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
A [auth L]IPR003966Prothrombin/thrombinFamily
A [auth L]IPR018114Serine proteases, trypsin family, histidine active siteActive Site
A [auth L]IPR009003Peptidase S1, PA clanHomologous Superfamily
A [auth L]IPR033116Serine proteases, trypsin family, serine active siteActive Site
A [auth L]IPR001254Serine proteases, trypsin domainDomain
A [auth L]IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
A [auth L]IPR000001KringleDomain
A [auth L]IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
A [auth L]IPR051659Serine Protease S1 Domain-Containing ProteinFamily
A [auth L]IPR018056Kringle, conserved siteConserved Site
A [auth L]IPR013806Kringle-like foldHomologous Superfamily
A [auth L]IPR038178Kringle superfamilyHomologous Superfamily
A [auth L]IPR001314Peptidase S1A, chymotrypsin familyFamily
A [auth L]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
B [auth H]Pharos:  P00734
A [auth L]Pharos:  P00734