3BPT
Crystal structure of human beta-hydroxyisobutyryl-CoA hydrolase in complex with quercetin
External Resource: Annotation
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.90.226.10 | Alpha Beta | Alpha-Beta Complex | 2-enoyl-CoA Hydratase | Chain A, domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF16113 | Enoyl-CoA hydratase/isomerase (ECH_2) | Enoyl-CoA hydratase/isomerase | This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from Pfam:PF00378 in the structure of it's ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR029045 | ClpP/crotonase-like domain superfamily | Homologous Superfamily | |
IPR032259 | Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type | Family | |
IPR045004 | Enoyl-CoA hydratase/isomerase domain | Domain |
Pharos: Disease Associations Pharos Homepage Annotation
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
Chains | Enzyme Name | Description | Catalytic Residues |
---|---|---|---|
3-hydroxyisobutyryl-CoA hydrolase M-CSA #345 | Hydrolyses 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyses 3-hydroxypropanoyl-CoA. Involved in the pathway L-valine degradation, which is part of Amino-acid degradation. A member of the crotonase superfamily. | Defined by 4 residues: GLY:A-68 [auth A-98]GLY:A-116 [auth A-146]GLU:A-139 [auth A-169]ASP:A-147 [auth A-177] | EC: 3.1.2.4 (PDB Primary Data) |