Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
B [auth H]d3c09h1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
B [auth H]d3c09h2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
E [auth C]d3c09c1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
E [auth C]d3c09c2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
C [auth A]d3c09a1 Alpha and beta proteins (a/b) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) L domain-like L domain EGF receptor extracellular domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth A]d3c09a2 Small proteins Knottins (small inhibitors, toxins, lectins) Growth factor receptor domain Growth factor receptor domain EGF receptor Cys-rich domains, C-terminal domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth A]d3c09a3 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth D]d3c09d1 Alpha and beta proteins (a/b) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) L domain-like L domain EGF receptor extracellular domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth D]d3c09d2 Small proteins Knottins (small inhibitors, toxins, lectins) Growth factor receptor domain Growth factor receptor domain EGF receptor Cys-rich domains, C-terminal domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth D]d3c09d3 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
C [auth A]SCOP2B SuperfamilyL domain-like 8038760 3001010 SCOP2B (2022-06-29)
C [auth A]SCOP2B SuperfamilyGrowth factor receptor domain-like 8038763 3000398 SCOP2B (2022-06-29)
F [auth D]SCOP2B SuperfamilyL domain-like 8038760 3001010 SCOP2B (2022-06-29)
F [auth D]SCOP2B SuperfamilyGrowth factor receptor domain-like 8038763 3000398 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
B [auth H]V-set_8e3c09H1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
B [auth H]C1-set_1e3c09H2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
E [auth C]V-set_8e3c09C4 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
E [auth C]C1-set_1e3c09C3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
C [auth A]Recep_L_domaine3c09A1 A: beta duplicates or obligate multimersX: Single-stranded right-handed beta-helixH: Leucine-rich repeats (From Topology)T: Leucine-rich repeatsF: Recep_L_domainECOD (1.6)
F [auth D]Recep_L_domaine3c09D1 A: beta duplicates or obligate multimersX: Single-stranded right-handed beta-helixH: Leucine-rich repeats (From Topology)T: Leucine-rich repeatsF: Recep_L_domainECOD (1.6)
A [auth L]C1-set_4e3c09L2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
A [auth L]V-sete3c09L1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
D [auth B]C1-set_4e3c09B3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
D [auth B]V-sete3c09B4 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
B [auth H],
E [auth C]
INN name VH-CH1 Humanized (humanized) IGHV1-46*01, IGHV1-46*03, IGHJ4*01, IGHJ4*02, IGHJ4*03, IGHG1*01, IGHG1*02, IGHG1*04 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202443-0)
A [auth L],
D [auth B]
INN name L-KAPPA Humanized (humanized) IGKV1-39*01, IGKV1D-39*01, IGKJ1*01, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202443-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
B [auth H],
E [auth C]
Heavy ChainIGHV1 -epidermal growth factor receptorSAbDab (2024-11-01)
A [auth L],
D [auth B]
Light ChainIGKV1 Kappaepidermal growth factor receptorSAbDab (2024-11-01)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
B [auth H],
E [auth C]
Matuzumab EGFR/ERBB1/HER1Therapeutic SAbDab (2024-11-01)
A [auth L],
D [auth B]
Matuzumab EGFR/ERBB1/HER1Therapeutic SAbDab (2024-11-01)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C [auth A],
F [auth D]
PF01030Receptor L domain (Recep_L_domain)Receptor L domain- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B [auth H],
E [auth C]
Matuzumab Fab Heavy chain---
C [auth A],
F [auth D]
Epidermal growth factor receptor
A [auth L],
D [auth B]
Matuzumab Fab Light chain---

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C [auth A],
F [auth D]
PharosP00533