3DT6

Crystal Structure of Bovin Brain Platelet Activating Factor Acetylhydrolase Covalently Inhibited by Paraoxon

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3dt6a_	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	automated matches	bovine,cow,domestic cattle,domestic cow (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SGNH hydrolase-like	8044119	3001315	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lipase_GDSL_2	e3dt6A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13472	GDSL-like Lipase/Acylhydrolase family (Lipase_GDSL_2)	GDSL-like Lipase/Acylhydrolase family	This family of presumed lipases and related enzymes are similar to Pfam:PF00657.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Brain Platelet-activating factor acetylhydrolase IB subunit alpha	hydrolase activity, acting on ester bonds 1-alkyl-2-acetylglycerophosphocholine esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity platelet-activating factor acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity hydrolase activity, acting on ester bonds 1-alkyl-2-acetylglycerophosphocholine esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity platelet-activating factor acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity identical protein binding protein homodimerization activity	lipid catabolic process catabolic process metabolic process primary metabolic process lipid metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex catalytic complex 1-alkyl-2-acetylglycerophosphocholine esterase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013830	SGNH hydrolase-type esterase domain	Domain
A	IPR036514	SGNH hydrolase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.